Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
2014 (English)In: European Journal of Medical Research, ISSN 2047-783X, Vol. 19, 61- p.Article in journal (Refereed) Published
Background: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.
Methods: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.
Results: Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.
Conclusion: Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.
Place, publisher, year, edition, pages
2014. Vol. 19, 61- p.
IdentifiersURN: urn:nbn:se:uu:diva-235764DOI: 10.1186/s40001-014-0061-9ISI: 000345944200001PubMedID: 25380724OAI: oai:DiVA.org:uu-235764DiVA: diva2:761880