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Information homeostasis as a fundamental principle governing the cell division and death
University of Freiburg, Germany .ORCID iD: 0000-0002-8044-9195
2011 (English)In: Medical Hypotheses, ISSN 0306-9877, E-ISSN 1532-2777, Vol. 77, no 3, 318-322 p.Article in journal (Refereed) Published
Abstract [en]

To express the genetic information with minimal error is one of the key functions of a cell. Here we propose an information theory based, phenomenological model for the expression of genetic information. Based on the model we propose the concept of 'information homeostasis' which ensures that genetic information is expressed with minimal error. We suggest that together with energy homeostasis, information homeostasis is a fundamental working principle of a biological cell. This model proposes a novel explanation of why a cell divides and why it stops to divide and, thus, provides novel insights into oncogenesis and various neuro-degenerative diseases. Moreover, the model suggests a theoretical framework to understand cell division and death, beyond specific biochemical pathways.

Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 77, no 3, 318-322 p.
National Category
Cancer and Oncology Bioinformatics and Systems Biology Bioinformatics (Computational Biology)
URN: urn:nbn:se:kth:diva-154847DOI: 10.1016/j.mehy.2011.05.003ISI: 000295183500002ScopusID: 2-s2.0-80051827920OAI: diva2:758932

QC 20150429

Available from: 2014-10-28 Created: 2014-10-28 Last updated: 2016-02-02Bibliographically approved

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