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A vital role for complement in heart disease
Nordland Hospital, Norway; University of Tromso, Norway.
Copenhagen University Hospital, Denmark.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping.
Norwegian University of Science and Technology, Norway.
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2014 (English)In: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 61, no 2, 126-134 p.Article, review/survey (Refereed) Published
Abstract [en]

Heart diseases are common and significant contributors to worldwide mortality and morbidity. During recent years complement mediated inflammation has been shown to be an important player in a variety of heart diseases. Despite some negative results from clinical trials using complement inhibitors, emerging evidence points to an association between the complement system and heart diseases. Thus, complement seems to be important in coronary heart disease as well as in heart failure, where several studies underscore the prognostic importance of complement activation. Furthermore, patients with atrial fibrillation often share risk factors both with coronary heart disease and heart failure, and there is some evidence implicating complement activation in atrial fibrillation. Moreover, Chagas heart disease, a protozoal infection, is an important cause of heart failure in Latin America, and the complement system is crucial for the protozoa-host interaction. Thus, complement activation appears to be involved in the pathophysiology of a diverse range of cardiac conditions. Determination of the exact role of complement in the various heart diseases will hopefully help to identify patients that might benefit from therapeutic complement intervention.

Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 61, no 2, 126-134 p.
Keyword [en]
Complement system; Myocardial infarction; Coronary heart disease; Heart failure; Atrial fibrillation; Chagas disease
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-111600DOI: 10.1016/j.molimm.2014.06.036ISI: 000342265300010PubMedID: 25037633OAI: diva2:758557
Available from: 2014-10-27 Created: 2014-10-27 Last updated: 2014-11-05

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Jonasson, Lena
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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Cardiology in Linköping
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