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Is S100A1 involved in the programming effects of fetal hypoxia on cardiac function in chickens?
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, The Institute of Technology.
2014 (English)Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Prolonged prenatal hypoxia has shown to cause fetal growth restriction inchickens due to restricted oxygen to the somatic tissue. The body goes through a critical periodof development. Insults during this critical period may have lifelong effects on the individual.Currently heart failure is treated either with symptomatic therapy using diuretics or by targetingthe renin-angiotensin-aldosterone system. Developing new successful treatments is importantwith the aging population and the increased rate of heart failure. Previous studies have shownsystolic contractile dysfunction in 5 week old broiler chicken hearts when the eggs have beenincubated in hypoxia until hatching. S100A1 in cardiomyocytes regulates the calcium-controllednetwork which plays a big role in cardiac contractility and in this study, using qPCR on S100A1(GOI), GADPH and β-actin to try and determine if the changes made to the heart while the fetusis developing is due to a lack of S100A1 expression resulting in a decreased handling of Ca2+uptake which causes contractile dysfunction A Roche Lightcycler 480 was used together with theRoche template running triplets of each sample at 15-15-15 seconds for 45 cycles No statisticalsignificance was observed between the control group and the experimental group. However inthis study only S100A1 gene is being considered but a better understanding of the whole S100family might give a better understanding of mechanisms causing the progressive deterioration ofcardiac function

Place, publisher, year, edition, pages
2014. , 11 p.
Keyword [en]
S100A1, gene expression, hypoxia, heart failure, gallus gallus
National Category
URN: urn:nbn:se:liu:diva-111556ISRN: LiTH-IFM- Ex--14/2906--SEOAI: diva2:757844
Subject / course
Available from: 2014-10-28 Created: 2014-10-23 Last updated: 2014-10-28Bibliographically approved

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Karalekas, Panagiotis
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