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Low dose PTH improves metaphyseal bone healing more when muscles are paralyzed
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. University of California, San Diego, USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
2014 (English)In: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 63, 15-19 p.Article in journal (Refereed) Published
Abstract [en]

Stimulation of bone formation by PTH is related to mechanosensitivity. The response to PTH treatment in intact bone could therefore be blunted by unloading. We studied the effects of mechanical loading on the response to PTH treatment in bone healing. Most fractures occur in the metaphyses, therefor we used a model for metaphyseal bone injury. One hind leg of 20 male SD rats was unloaded via intramuscular botulinum toxin injections. Two weeks later, the proximal unloaded tibia had lost 78% of its trabecular contents. At this time-point, the rats received bilateral proximal tibiae screw implants. Ten of the 20 rats were given daily injections of 5 μg/kg PTH (1-34). After two weeks of healing, screw fixation was measured by pull-out, and microCT of the distal femur cancellous compartment was performed. Pull-out force provided an estimate for cancellous bone formation after trauma. PTH more than doubled the pull-out force in the unloaded limbs (from 14 to 30 N), but increased it by less than half in the loaded ones (from 30 to 44 N). In relative terms, PTH had a stronger effect on pull-out force in unloaded bone than in loaded bone (p=0.03). The results suggest that PTH treatment for stimulation of bone healing does not require simultaneous mechanical stimulation.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 63, 15-19 p.
Keyword [en]
Botulinum toxin; Fracture healing; Mechanical loading; Metaphyseal fracture; Parathyroid hormone
National Category
Clinical Medicine Orthopedics
Identifiers
URN: urn:nbn:se:liu:diva-111393DOI: 10.1016/j.bone.2014.02.008ISI: 000335094200003PubMedID: 24582802ScopusID: 2-s2.0-84896034433OAI: oai:DiVA.org:liu-111393DiVA: diva2:756101
Available from: 2014-10-16 Created: 2014-10-16 Last updated: 2015-04-09Bibliographically approved

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Sandberg, OlofAspenberg, Per
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Orthopaedics in Linköping
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