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A system for remote dosimetry audit of 3D-CRT, IMRT and VMAT based on lithium formate dosimetry
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Biomedical Engineering.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-0209-498X
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2014 (English)In: Radiotherapy and Oncology, ISSN 0167-8140, E-ISSN 1879-0887, Vol. 113, no 2, 279-282 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this work was to develop and test a remote end-to-end audit system using lithium formate EPR dosimeters. Four clinics were included in a pilot study, absorbed doses determined in the PTV agreed with TPS calculated doses within ±5% for 3D-CRT and ±7% (k=1) for IMRT/VMAT dose plans.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 113, no 2, 279-282 p.
Keyword [en]
Dosimetry audit; remote audit; end-to-end; EPR; ESR; lithium formate
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-111089DOI: 10.1016/j.radonc.2014.11.027ISI: 000347657200021OAI: oai:DiVA.org:liu-111089DiVA: diva2:753200
Available from: 2014-10-07 Created: 2014-10-07 Last updated: 2017-12-05Bibliographically approved
In thesis
1. Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
Open this publication in new window or tab >>Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Lithium formate has shown to be a material with properties suitable for electron paramagnetic resonance (EPR) dosimetry, among them up to 7 times higher sensitivity compared to alanine, which is a well-established EPR detector material for dose determinations in radiotherapy.

The aim of this thesis was to further investigate the properties of lithium formate and develop the dosimetry system towards applications in radiotherapy. The intrinsic efficiency for energies of relevance to brachytherapy and the signal stability were investigated. The dosimetry system was expanded to include a smaller dosimeter model, suitable for measurements in dose gradient regions. An individual sensitivity correction method was applied to the smaller dosimeters to be able to perform dose determinations with the same precision as for the larger ones. EPR dosimetry in general is time consuming and effort was spent to optimize the signal readout procedure regarding measurement time and measurement precision.

The system was applied in two clinical applications chosen for their high demands on the dosimetry system: 1) a dosimetry audit for external photon beam therapy and 2) dose verification measurements around a low energy HDR brachytherapy source.

The conclusions drawn from this thesis were: dose determinations can be performed with a standard uncertainty of 1.8-2.5% using both the original size dosimeters and the new developed smaller ones. The dosimetry system is robust and useful for applications when high measurement precision and accuracy is prioritized. It is a good candidate for dosimetry audits, both in external beam therapy and brachytherapy.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 51 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1417
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-111091 (URN)10.3384/diss.diva-111091 (DOI)978-91-7519-246-8 (ISBN)
Public defence
2014-11-06, Eken, ingång 65, plan 9, Campus US, Linköpings universitet, Linköping, 09:00 (English)
Opponent
Supervisors
Available from: 2014-10-07 Created: 2014-10-07 Last updated: 2015-03-20Bibliographically approved

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Adolfsson, EmelieGustafsson, HåkanLund, EvaAlm Carlsson, GudrunCarlsson Tedgren, Åsa

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Adolfsson, EmelieGustafsson, HåkanLund, EvaAlm Carlsson, GudrunCarlsson Tedgren, Åsa
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Division of Radiological SciencesFaculty of Health SciencesDepartment of Biomedical EngineeringCenter for Medical Image Science and Visualization (CMIV)Department of Radiation Physics
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