Change search
ReferencesLink to record
Permanent link

Direct link
Identification of potential plasma biomarkers of inflammation in farmers with musculoskeletal disorders: A proteomic study
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
2012 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

In this thesis we look for potential chronic inflammation biomarkers because studies have shown that farmers with musculoskeletal disorders might be affected by the environment to develop musculoskeletal disorders. Animal farmers are highly exposed to dust, aerosols, molds and other toxins in the air and environment leading to musculoskeletal disorders, respiratory disorders, airway symptoms and febrile reactions. There is reason to believe that the farmers have a constant or chronic inflammation that develops into musculoskeletal disorders. By using a proteomic approach with Two-dimensional Gel Electrophoresis and silver staining our goal was to find biomarkers by quantifying protein spots that differ significantly from farmers with musculoskeletal disorders compared to rural controls. In our study we found 8 significant proteins, two from Alpha-2-HS-glycoprotein, one from Apolipoprotein A1, three from Haptoglobin, one from Hemopexin and 1 from Antithrombin. All 5 proteins are involved in inflammation response in some way and some proteins are linked to chronic inflammation. Out of the 5 proteins Alpha-2-HS-glycoprotein, Apolipoprotein A1 and Hemopexin seem like the most likely proteins to investigate further as potential inflammation biomarkers.

Place, publisher, year, edition, pages
2012. , 53 p.
Keyword [en]
Proteomics, biomarkers, two-dimensional gel electrophoresis, musculoskeletal disorders, environment
National Category
Analytical Chemistry
URN: urn:nbn:se:liu:diva-110782ISRN: LITH-IFM-A-EX--14/2948--SEOAI: diva2:748942
Subject / course
Chemical Biology
Available from: 2015-06-01 Created: 2014-09-22 Last updated: 2015-06-01Bibliographically approved

Open Access in DiVA

fulltext(2844 kB)71 downloads
File information
File name FULLTEXT01.pdfFile size 2844 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Carlsson, Anders
By organisation
ChemistryThe Institute of Technology
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 71 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 67 hits
ReferencesLink to record
Permanent link

Direct link