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Deciphering the mechanisms of binding induced folding at nearly atomic resolution: The Φ value analysis applied to IDPs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2014 (English)In: Intrinsically Disordered Proteins, ISSN 2169-0707, Vol. 2, no 1, e28624- p.Article in journal (Refereed) Published
Abstract [en]

The Φ value analysis is a method to analyze the structure of metastable states in reaction pathways. Such a methodology is based on the quantitative analysis of the effect of point mutations on the kinetics and thermodynamics of the probed reaction. The Φ value analysis is routinely used in protein folding studies and is potentially an extremely powerful tool to analyze the mechanism of binding induced folding of intrinsically disordered proteins. In this review we recapitulate the key equations and experimental advices to perform the Φ value analysis in the perspective of the possible caveats arising in intrinsically disordered systems. Finally, we briefly discuss some few examples already available in the literature.

Place, publisher, year, edition, pages
2014. Vol. 2, no 1, e28624- p.
National Category
Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-232466DOI: 10.4161/idp.28624OAI: oai:DiVA.org:uu-232466DiVA: diva2:748179
Available from: 2014-09-18 Created: 2014-09-18 Last updated: 2014-09-18Bibliographically approved

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CiteExportLink to record
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