Change search
ReferencesLink to record
Permanent link

Direct link
Oral-parenteral conversion factor for morphine in palliative cancer care: a prospective randomized crossover pilot study
Department of Internal Medicine, Östersund Hospital.
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. Göteborgs universitet.ORCID iD: 0000-0001-9623-5813
2011 (English)In: Pain Research and Treatment, ISSN 2090-1542, E-ISSN 2090-1550, Vol. 2011, 504034Article in journal (Refereed) Published
Abstract [en]

Objective. This pilot study clinically tests whether a conversion factor of 2 to 1 is appropriate when changing from oral to parenteral morphine administration in the treatment of cancer-related nociceptive pain and calculates the size of an adequately powered future study. Methods. Eleven outpatients with incurable cancer and well-controlled nociceptive pain were randomly assigned to either intravenous or subcutaneous morphine using half the previous oral 24-hour dose. Each group crossed over after the first three-day period. Serum concentrations of morphine and its metabolites were monitored as well as intensity of pain. Results. Oral to subcutaneous and oral to intravenous quotas of morphine concentrations were approximately 0.9. Subcutaneous to intravenous morphine quotas were 1. Conclusions. The conversion factor of 2 to 1 seems to be a reasonable average but with an obvious need for individual adjustments. Concurrent medications and substantially higher doses of morphine could potentially affect the appropriate conversion factor. An adequately powered study to validate these findings would need at least 121 patients.

Place, publisher, year, edition, pages
2011. Vol. 2011, 504034
National Category
Medical and Health Sciences
URN: urn:nbn:se:miun:diva-22917DOI: 10.1155/2011/504034ScopusID: 2-s2.0-84873850871OAI: diva2:746042
Available from: 2014-09-11 Created: 2014-09-11 Last updated: 2016-09-29Bibliographically approved

Open Access in DiVA

fulltext(511 kB)104 downloads
File information
File name FULLTEXT01.pdfFile size 511 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Melin-Johansson, Christina
By organisation
Department of Health Sciences
In the same journal
Pain Research and Treatment
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 104 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 48 hits
ReferencesLink to record
Permanent link

Direct link