Change search
ReferencesLink to record
Permanent link

Direct link
Influence of a prudent diet on circulating cathepsin S in humans
Dalarna University, School of Education, Health and Social Studies, Medical Science. Uppsala universitetet.
Dalarna University, School of Education, Health and Social Studies, Medical Science.
Show others and affiliations
2014 (English)In: Nutrition Journal, ISSN 1475-2891, E-ISSN 1475-2891, Vol. 13, no 84Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Increased circulating cathepsin S levels have been linked to increased risk of cardiometabolic diseases and cancer. However, whether cathepsin S is a modifiable risk factor is unclear. We aimed to investigate the effects of a prudent diet on plasma cathepsin S levels in healthy individuals.

FINDINGS: Explorative analyses of a randomized study were performed in 88 normal to slightly overweight and hyperlipidemic men and women (aged 25 to 65) that were randomly assigned to ad libitum prudent diet, i.e. healthy Nordic diet (ND) or a control group (habitual Western diet) for 6 weeks. Whereas all foods in the ND were provided, the control group was advised to consume their habitual diet throughout the study. The ND was in line with dietary recommendations, e.g. low in saturated fats, sugars and salt, but high in plant-based foods rich in fibre and unsaturated fats.The ND significantly decreased cathepsin S levels (from 20.1 (+/-4.0 SD) to 19.7 μg/L (+/-4.3 SD)) compared with control group (from 18.2 (+/-2.9 SD) to 19.1 μg/L (+/-3.8 SD)). This difference remained after adjusting for sex and change in insulin sensitivity (P = 0.03), and near significant after adjusting for baseline cathepsin S levels (P = 0.06), but not for change in weight or LDL-C. Changes in cathepsin S levels were directly correlated with change in LDL-C.

CONCLUSIONS: Compared with a habitual control diet, a provided ad libitum healthy Nordic diet decreased cathepsin S levels in healthy individuals, possibly mediated by weight loss or lowered LDL-C. These differences between groups in cathepsin S were however not robust and therefore need further investigation.

Place, publisher, year, edition, pages
BioMed Central, 2014. Vol. 13, no 84
Keyword [en]
Nordic prudent diet; Cathepsin S; Weight loss; Cardiometabolic risk factors
National Category
Clinical Medicine
Research subject
Health and Welfare
URN: urn:nbn:se:du-15286DOI: 10.1186/1475-2891-13-84ISI: 000341112000001PubMedID: 25128296OAI: diva2:745014
Available from: 2014-09-09 Created: 2014-09-09 Last updated: 2016-05-31Bibliographically approved

Open Access in DiVA

fulltext(224 kB)25 downloads
File information
File name FULLTEXT01.pdfFile size 224 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jobs, ElisabethJobs, MagnusNerpin, ElisabetÄrnlöv, Johan
By organisation
Medical Science
In the same journal
Nutrition Journal
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 25 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 509 hits
ReferencesLink to record
Permanent link

Direct link