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Biochemical and Metabolic Modeling and Simulation with Modelica
Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-3435-4996
2005 (English)In: BioMedSim 2005. Proceedings of the Conference on Modeling and Simulation in Biology, Medicine and Biomedical Engineering, May 26-27, 2005, Linköping, Sweden / [ed] Peter Fritzson, 2005, 115-124 p.Conference paper, Published paper (Refereed)
Abstract [en]

In the drug industry, the later a substance is discharged from the drug development pipeline, the higher the financial cost. In order to reduce the number of lead compounds a number of computerized systems have been suggested, and in most of these systems modeling and simulation of the lead compound’s effects on different metabolic pathways are essential. Inthese systems, substances that are expected to be harmful or lethal can be removed at an early stage and a reduced number of lead compounds can be chosen for the concluding tests.

Given Modelica’s previous success with modeling and simulation of huge and complex systems it is likely that it will also be suitable for modeling, simulation, and visualization of metabolic pathway systems, e.g. those systems used in the drug industry. A Modelica library designed to be used for modeling, simulation, and visualization of metabolic pathways is the specialpurpose library Metabolic, an extension of the abstract Modelica library BioChem.

Place, publisher, year, edition, pages
2005. 115-124 p.
Keyword [en]
Pathway modeling, pathway libraries, template models, BioChem, Metabolic.
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:liu:diva-110204OAI: oai:DiVA.org:liu-110204DiVA: diva2:743524
Conference
4th International Conference on Modeling and Simulation in Biology, Medicine, and Biomedical Engineering (BioMedSim’2005), Linköping, Sweden, May 26-27
Available from: 2014-09-04 Created: 2014-09-04 Last updated: 2014-10-14Bibliographically approved

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