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Light-induced vibration in the hearing organ
Oregon Health and Science University, OR 97239 USA .
Oregon Health and Science University, OR 97239 USA .
University of Michigan, MI 48109 USA .
University of Michigan, MI 48109 USA.
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2014 (English)In: Scientific Reports, ISSN 2045-2322, Vol. 4, 5941- p.Article in journal (Refereed) Published
Abstract [en]

The exceptional sensitivity of mammalian hearing organs is attributed to an active process, where force produced by sensory cells boost sound-induced vibrations, making soft sounds audible. This process is thought to be local, with each section of the hearing organ capable of amplifying sound-evoked movement, and nearly instantaneous, since amplification can work for sounds at frequencies up to 100 kHz in some species. To test these fundamental precepts, we developed a method for focally stimulating the living hearing organ with light. Light pulses caused intense and highly damped mechanical responses followed by traveling waves that developed with considerable delay. The delayed response was identical to movements evoked by click-like sounds. This shows that the active process is neither local nor instantaneous, but requires mechanical waves traveling from the cochlear base toward its apex. A physiologically-based mathematical model shows that such waves engage the active process, enhancing hearing sensitivity.

Place, publisher, year, edition, pages
Nature Publishing Group: Open Access Journals - Option B / Nature Publishing Group , 2014. Vol. 4, 5941- p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-109872DOI: 10.1038/srep05941ISI: 000339941900001PubMedID: 25087606OAI: diva2:741629

Funding Agencies|NIH [DC-004554, DC-004084]; Swedish Research Council [K2011-63X-14061-11-39]; Research Council for Health, Working Life and Welfare [2006-1526]; Horselskadades Riksforbund; Tysta skolan foundation

Available from: 2014-08-28 Created: 2014-08-28 Last updated: 2014-09-02

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