An Overview of Brevinin Superfamily: Structure, Function and Clinical Perspectives
2014 (English)In: Anticancer Genes / [ed] Stefan Grimm, Springer London, 2014, 197-212 p.Chapter in book (Refereed)
Antimicrobial peptides are the backbone of first-line defense againstvarious microorganisms in the animal kingdom. Thus, not surprisingly, they aregaining attention in the science and medical fields as a rich repository of newpro-drugs. Below, we focus our attention on the Brevinin family of anuran peptides.While most of them show strong antibacterial activities, some, e.g. Brevinin-2R,appear to be promising anticancer molecules, exhibiting better a therapeutic windowthan widely-use anticancer drugs like doxorubicin. We briefly introduce thefield, followed by highlighting the promising therapeutic properties of Brevinins.Next, we provide information about the cloning and phylogenetic aspects ofBrevinin genes. In the final paragraphs of this chapter, we discuss possible largescaleproduction methods of Brevinins, giving examples of some systems that arealready in use. Towards the end, we discuss various means of modification ofbiologic properties of Brevinins, either by chemical modifications or by aminoacid substitution and sequence rearrangements. In this context, also other uniqueproperties of Brevinins are briefly mentioned. Finally, we discuss the future of theBrevinin field, particularly highlighting yet to be answered biologic questions, likefor example presumed anti-viral and antitumor activities of Brevinin familymembers.
Place, publisher, year, edition, pages
Springer London, 2014. 197-212 p.
, Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; Vol. 818
Amidophosphoribosyltransferase, Bionanomaterials, Brevinin, Bufodienolides, Bufogenines, Cathepsin, Esculentin, Hypoglycemia, Japonicin, Magainins, Nanocarrier, Nigrocin, Palustrin, Peptidomimetica, Phosphatidylserines, Rana box, Ranacyclin, Ranalexin, Ranateurin, Ranid frogs, Temporin
IdentifiersURN: urn:nbn:se:liu:diva-109700DOI: 10.1007/978-1-4471-6458-6_10ISI: 000350424100010ISBN: 978-1-4471-6457-9OAI: oai:DiVA.org:liu-109700DiVA: diva2:740630
PMID: 250015382014-08-252014-08-252015-04-07Bibliographically approved