Exploring innate type B cells in an animal model for autoimmune arthritis
Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
B cells have a central role in the pathogenesis of collagen-induced arthritis (CIA), an animal model of the autoimmune disease rheumatoid arthritis. In this report, a specific subset of an innate type of B cells, B-1 B cells, have been studied for the involvement in CIA. The B-1 B cells were shown to produce small amounts of collagen-specific antibodies upon stimulation in vitro, suggesting that they play a minor role in the development of CIA. This report also includes how marginal zone B cells, another innate type of B cells with natural collagen-reactivity, can be identified in the medullary sinuses of lymph nodes of collagen-immunized mice, implying involvement in auto antigen trapping.
Place, publisher, year, edition, pages
2014. , 28 p.
, UPTEC X 14 022
Rheumatoid arthritis, collagen-induced arthritis, B-1 B cells, MZB, MZBL, antibodies, polyreactive antibodies, collagen-specific antibodies, MACS, FACS, ELISA, ELISPOT, IHC.
Biomedical Laboratory Science/Technology Immunology
IdentifiersURN: urn:nbn:se:uu:diva-229792OAI: oai:DiVA.org:uu-229792DiVA: diva2:737809
Molecular Biotechnology Engineering Programme
Kleinau, Sandra, Professor
Henriksson, LenaKrabbe, Margareta