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Exploring innate type B cells in an animal model for autoimmune arthritis
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2014 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

B cells have a central role in the pathogenesis of collagen-induced arthritis (CIA), an animal model of the autoimmune disease rheumatoid arthritis. In this report, a specific subset of an innate type of B cells, B-1 B cells, have been studied for the involvement in CIA. The B-1 B cells were shown to produce small amounts of collagen-specific antibodies upon stimulation in vitro, suggesting that they play a minor role in the development of CIA. This report also includes how marginal zone B cells, another innate type of B cells with natural collagen-reactivity, can be identified in the medullary sinuses of lymph nodes of collagen-immunized mice, implying involvement in auto antigen trapping.    

Place, publisher, year, edition, pages
2014. , 28 p.
, UPTEC X 14 022
Keyword [en]
Rheumatoid arthritis, collagen-induced arthritis, B-1 B cells, MZB, MZBL, antibodies, polyreactive antibodies, collagen-specific antibodies, MACS, FACS, ELISA, ELISPOT, IHC.
National Category
Biomedical Laboratory Science/Technology Immunology
URN: urn:nbn:se:uu:diva-229792OAI: diva2:737809
Educational program
Molecular Biotechnology Engineering Programme
Available from: 2014-08-14 Created: 2014-08-13 Last updated: 2014-08-18Bibliographically approved

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