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Low gut microbiota diversity in early infancy precedes asthma at school age
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Karolinska Institute, Stockholm, Sweden.
KTH Royal Institute of Technology, Stockholm, Sweden.
Karolinska Institute, Stockholm, Sweden; Örebro University, Sweden .
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2014 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 44, no 6, 842-850 p.Article in journal (Refereed) Published
Abstract [en]


Low total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age.


To assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to the prevalence of different allergic diseases in school age, such as asthma, allergic rhinoconjunctivitis (ARC) and eczema.


The microbial diversity and composition was analysed with barcoded 16S rDNA 454 pyrosequencing in stool samples at 1 week, 1 month and 12 months of age in 47 infants which were subsequently assessed for allergic disease and skin prick test reactivity at 7 years of age ( ID NCT01285830).


Children developing asthma (n = 8) had a lower diversity of the total microbiota than non-asthmatic children at 1 week (P = 0.04) and 1 month (P = 0.003) of age, whereas allergic rhinoconjunctivitis (n = 13), eczema (n = 12) and positive skin prick reactivity (n = 14) at 7 years of age did not associate with the gut microbiota diversity. Neither was asthma associated with the microbiota composition later in infancy (at 12 months). Children having IgE-associated eczema in infancy and subsequently developing asthma had lower microbial diversity than those that did not. There were no significant differences, however, in relative abundance of bacterial phyla and genera between children with or without allergic disease.


Low total diversity of the gut microbiota during the first month of life was associated with asthma but not ARC in children at 7 years of age. Measures affecting microbial colonization of the infant during the first month of life may impact asthma development in childhood.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 44, no 6, 842-850 p.
Keyword [en]
asthma; allergic rhinoconjunctivitis; birth; children; diversity; hygiene hypothesis; microbiota; molecular microbiology
National Category
Clinical Medicine Cell and Molecular Biology Microbiology in the medical area
URN: urn:nbn:se:liu:diva-109137DOI: 10.1111/cea.12253ISI: 000337529100006PubMedID: 24330256OAI: diva2:737516
Available from: 2014-08-13 Created: 2014-08-11 Last updated: 2015-03-30Bibliographically approved

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Abrahamsson, ThomasJenmalm, Maria
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in LinköpingDivision of Inflammation Medicine
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Clinical MedicineCell and Molecular BiologyMicrobiology in the medical area

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