Change search
ReferencesLink to record
Permanent link

Direct link
Costs for collagenase injections compared with fasciectomy in the treatment of Dupuytren's contracture: a retrospective cohort study
Hässleholm Hospital, Sweden; Lund University, Sweden .
Hässleholm Hospital, Sweden.
Hässleholm Hospital, Sweden.
Hässleholm Hospital, Sweden.
Show others and affiliations
2014 (English)In: BMJ Open, ISSN 2044-6055, Vol. 4, no 1, e004166- p.Article in journal (Refereed) Published
Abstract [en]


To compare collagenase injections and surgery (fasciectomy) for Dupuytren's contracture (DC) regarding actual total direct treatment costs and short-term outcomes.


Retrospective cohort study.


Orthopaedic department of a regional hospital in Sweden.


Patients aged 65 years or older with previously untreated DC of 30° or greater in the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joints of the small, ring or middle finger. The collagenase group comprised 16 consecutive patients treated during the first 6 months following the introduction of collagenase as treatment for DC at the study centre. The controls were 16 patients randomly selected among those operated on with fasciectomy at the same centre during the preceding 3 years.


Treatment with collagenase was given during two standard outpatient clinic visits (injection of 0.9 mg, distributed at multiple sites in a palpable cord, and next-day finger extension under local anaesthesia) followed by night-time splinting. Fasciectomy was carried out in the operating room (day surgery) under general or regional anaesthesia using standard technique, followed by therapy and splinting.


Actual total direct costs (salaries of all medical personnel involved in care, medications, materials and other relevant costs), and total MCP and PIP extension deficit (degrees) measured by hand therapists at 6-12 weeks after the treatment.


Collagenase injection required fewer hospital outpatient visits to a therapist and nurse than fasciectomy. Total treatment cost for collagenase injection was US$1418.04 and for fasciectomy US$2102.56. The post-treatment median (IQR) total extension deficit was 10 (0-30) for the collagenase group and 10 (0-34) for the fasciectomy group.


Treatment of DC with one collagenase injection costs 33% less than fasciectomy with equivalent efficacy at 6 weeks regarding reduction in contracture.

Place, publisher, year, edition, pages
BMJ Publishing Group , 2014. Vol. 4, no 1, e004166- p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-109159DOI: 10.1136/bmjopen-2013-004166ISI: 000337363700033PubMedID: 24435894OAI: diva2:737490
Available from: 2014-08-13 Created: 2014-08-11 Last updated: 2015-03-31Bibliographically approved

Open Access in DiVA

fulltext(911 kB)140 downloads
File information
File name FULLTEXT01.pdfFile size 911 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Waldén, Markus
By organisation
Division of Community MedicineFaculty of Health Sciences
In the same journal
BMJ Open
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 140 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 92 hits
ReferencesLink to record
Permanent link

Direct link