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The Microbial Detection Array for Detection of Emerging Viruses in Clinical Samples - A Useful Panmicrobial Diagnostic Tool
Statens Serum Institut, Copenhagen, Denmark.
Lawrence Livermore National Laboratory, CA USA .
Statens Serum Institut, Copenhagen, Denmark.
Aristotle University of Thessaloniki, Greece .
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2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 6, e0100813- p.Article in journal (Refereed) Published
Abstract [en]

Emerging viruses are usually endemic to tropical and sub-tropical regions of the world, but increased global travel, climate change and changes in lifestyle are believed to contribute to the spread of these viruses into new regions. Many of these viruses cause similar disease symptoms as other emerging viruses or common infections, making these unexpected pathogens difficult to diagnose. Broad-spectrum pathogen detection microarrays containing probes for all sequenced viruses and bacteria can provide rapid identification of viruses, guiding decisions about treatment and appropriate case management. We report a modified Whole Transcriptome Amplification (WTA) method that increases unbiased amplification, particular of RNA viruses. Using this modified WTA method, we tested the specificity and sensitivity of the Lawrence Livermore Microbial Detection Array (LLMDA) against a wide range of emerging viruses present in both non-clinical and clinical samples using two different microarray data analysis methods.

Place, publisher, year, edition, pages
Public Library of Science , 2014. Vol. 9, no 6, e0100813- p.
National Category
Clinical Medicine
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URN: urn:nbn:se:liu:diva-109262DOI: 10.1371/journal.pone.0100813ISI: 000338709500083PubMedID: 24963710OAI: oai:DiVA.org:liu-109262DiVA: diva2:737149
Available from: 2014-08-12 Created: 2014-08-11 Last updated: 2017-12-05Bibliographically approved

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