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Recent advances in the design of artificial corneas
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-1222-6720
Queensland University of Technology, and Queensland Eye Institute, South Brisbane, QLD, Australia.
2014 (English)In: Current Opinion in Ophthalmology, ISSN 1040-8738, E-ISSN 1531-7021, Vol. 25, no 3, 240-247 p.Article, review/survey (Refereed) Published
Abstract [en]


Artificial corneas are being developed to meet a shortage of donor corneas and to address cases in which allografting is contraindicated. A range of artificial corneas has been developed. Here we review several newer designs and especially those inspired by naturally occurring biomaterials found with the human body and elsewhere.


Recent trends in the development of artificial corneas indicate a move towards the use of materials derived from native sources including decellularized corneal tissue and tissue substitutes synthesized by corneal cells in vitro when grown either on their own or in conjunction with novel protein-based scaffolds. Biologically inspired materials are also being considered for implantation on their own with the view to promoting endogenous corneal tissue.


More recent attempts at making artificial corneas have taken a more nature-based or nature-inspired approach. Several will in the near future be likely to be available clinically.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2014. Vol. 25, no 3, 240-247 p.
Keyword [en]
biomaterials; clinical observations; cornea; transplantation
National Category
URN: urn:nbn:se:liu:diva-107843DOI: 10.1097/ICU.0000000000000049ISI: 000334461400014PubMedID: 24663067OAI: diva2:727878
Available from: 2014-06-23 Created: 2014-06-23 Last updated: 2014-11-14

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