Role of Selective Estrogen Receptors B Agonist on Chronic Lymphocytic Leukemia Growth in Vitro
Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
The estrogen receptor alpha (ERa) and estrogen receptor beta (ER~) have been demonstrated to be important for immune system regulation and studies have suggested an antiproliferative effect of ER~ in lymphoid malignancies. We have studied the expression of ERa and ER~ in peripheral blood mononuclear cells from patients with chronic lymphocytic leukemia (CLL). Expression of ERa was low, while ER~ was highly expressed in CLL cells. In order to investigate the possible inhibitory effect of ligand-activated ER~ , we treated CLL cells and Mecl cell lines with the selective ER~ agonist diarypropionitrile (DPN) in culture. Treating Mecl cell lines with DPN showed an antiproliferative effect of ER~ agonist by significantly inhibit the growth of Mec 1 cell lines. This suggests that ER~ agonist may be useful in the treatment of CLL.
Place, publisher, year, edition, pages
2014. , 25 p.
Chronic lymphocytic leukemia, diarypropionitrile, estrogen receptor B
IdentifiersURN: urn:nbn:se:oru:diva-35412OAI: oai:DiVA.org:oru-35412DiVA: diva2:726414
Subject / course
Olsson, Per-Erik, Professor