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Role of Selective Estrogen Receptors B Agonist on Chronic Lymphocytic Leukemia Growth in Vitro
Örebro University, School of Science and Technology, Örebro University, Sweden.
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

The estrogen receptor alpha (ERa) and estrogen receptor beta (ER~) have been demonstrated to be important for immune system regulation and studies have suggested an antiproliferative effect of ER~ in lymphoid malignancies. We have studied the expression of ERa and ER~ in peripheral blood mononuclear cells from patients with chronic lymphocytic leukemia (CLL). Expression of ERa was low, while ER~ was highly expressed in CLL cells. In order to investigate the possible inhibitory effect of ligand-activated ER~ , we treated CLL cells and Mecl cell lines with the selective ER~ agonist diarypropionitrile (DPN) in culture. Treating Mecl cell lines with DPN showed an antiproliferative effect of ER~ agonist by significantly inhibit the growth of Mec 1 cell lines. This suggests that ER~ agonist may be useful in the treatment of CLL.

Place, publisher, year, edition, pages
2014. , 25 p.
Keyword [en]
Chronic lymphocytic leukemia, diarypropionitrile, estrogen receptor B
National Category
Biological Sciences
URN: urn:nbn:se:oru:diva-35412OAI: diva2:726414
Subject / course
Available from: 2014-06-18 Created: 2014-06-18 Last updated: 2014-06-18Bibliographically approved

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School of Science and Technology, Örebro University, Sweden
Biological Sciences

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