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The effects of oats on the function of gut microflora in children with coeliac disease
Karolinska Institute, Sweden Norrkoping Hospital, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
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2014 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 39, no 10, 1156-1160 p.Article in journal (Refereed) Published
Abstract [en]

Background Faecal short chain fatty acids (SCFAs) are produced by the gut microflora. We have previously reported high faecal SCFA levels in children with coeliac disease (CD), indicating alteration in gut microfloral metabolism. Data accumulated over recent decades by us and others suggest that wheat-free oats can safely be included in a gluten-free diet (GFD). However, concerns have been raised with respect to the safety of oats in a subset of coeliacs. Aim To describe faecal SCFA patterns in children with newly diagnosed CD treated for 1year with a GFD with or without oats. Methods This report is part of a randomised, double-blind study on the effect of a GFD containing oats (GFD-oats) vs. a standard GFD (GFD-std). Faecal samples were received from 34 children in the GFD-oats group and 37 in the GFD-std group at initial diagnosis and/or after 1year on a GFD. Faecal SCFAs were analysed. Results The GFD-std group had a significantly lower total faecal SCFA concentration at 12months compared with 0months (Pless than0.05). In contrast, total SCFA in the GFD-oats group remained high after 1year on the GFD. The children in the GFD-oats group had significantly higher acetic acid (Pless than0.05), n-butyric acid (Pless than0.05) and total SCFA concentration (Pless than0.01) after 1-year diet treatment compared to the GFD-std group. Conclusions Our results indicate that oats do affect the gut microflora function, and that some coeliac children receiving oats may develop gut mucosal inflammation, that may present a risk for future complications.

Place, publisher, year, edition, pages
Wiley , 2014. Vol. 39, no 10, 1156-1160 p.
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Clinical Medicine
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URN: urn:nbn:se:liu:diva-106829DOI: 10.1111/apt.12707ISI: 000334304200013OAI: oai:DiVA.org:liu-106829DiVA: diva2:720189
Available from: 2014-05-28 Created: 2014-05-23 Last updated: 2017-12-05

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Stenhammar, LarsSundqvist, TommyFälth-Magnusson, KarinHollén, ElisabetMagnusson, Karl-EricHögberg, Lotta
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in NorrköpingDepartment of Paediatrics in LinköpingDivision of Microbiology and Molecular Medicine
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