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Increased Functionality of Optical Fibers for Life-Science Applications
KTH, School of Engineering Sciences (SCI), Applied Physics, Quantum Electronics and Quantum Optics, QEO.
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The objective of this thesis work is to increase the functionality of optical fibers for possible applications in life-sciences. Optical fibers are a promising technology for use in biology and medicine. They are low-costwaveguides, flexible and have a small cross-section. They can guide high-power light with low loss in a micrometer core-size. These features make fibers attractive for minimally-invasive,in-vivostudies. The backwards guidance of the optical signal allows for real-time monitoring of the distance to the scattering targets and to study the environment through Raman scattering and fluorescence excitation. The longitudinal holes introduced in the fibers can be used,for instance,for delivery of medicine to a specific regionof a body. They could even be used for the extractionof species considered interesting for further analysis, for example, studyingcells that may be cancer-related.

This thesis deals with four main topics. First, a demonstration is presented of the combination of high-power light guidance for ablation, low-power light reflectometry for positioning, and for liquid retrieval in a single fiber. It was found that in order to exploit the microfluidic possibilities available in optical fibers with holes, one needs to be able to combine fluids and light in a fiber without hindering the low-loss light guidance and the fluid flow. Secondly, one should also be able to couple light into the liquids and backout again. This is the subject of another paper in the present thesis. It was also observed that laser excitation through a fiber for the collection of a low-intensity fluorescence signal was often affected by the luminescence noise createdby the primary-coating of the fiber. This problem makes it difficult to measure low light-levels, for example, from single-cells. Athirdpaper in this thesis then describes a novel approach to reduce the luminescence from the polymer coating of the fiber, with the use of a nanometer-thick carbon layer on the cladding surface. Finally, exploiting some of the results described earlier, an optical fiber with longitudinal holes is used for the excitation, identification and for the collection of particles considered being of interest. The excitation light is guided in the fiber, the identification is performed by choosing the fluorescent particles with the appropriate wavelength, and, when a particle of interest is sufficiently near the fiber-tip, the suction system is activated for collection of the particle with good specificity.

It is believed that the work described in this thesis could open the doors for applications in life-sciences and the future use of optical fibers for in-vivo studies.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2014. , xii, 63 p.
Series
TRITA-FYS, ISSN 0280-316X ; 2014:15
Keyword [en]
Fiberoptics, microstructured fiber, fiber - based optofluidics, laser ablation, microfluidics, reflectometry, fluorescence detection, fiber - based spectroscopy
National Category
Other Physics Topics
Research subject
Physics
Identifiers
URN: urn:nbn:se:kth:diva-145319ISBN: 978-91-7595-122-5 (print)OAI: oai:DiVA.org:kth-145319DiVA: diva2:717562
Public defence
2014-05-21, sal FB5, AlbaNova Universitetscentrum, Roslagstullsbacken 21, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20140516

Available from: 2014-05-16 Created: 2014-05-15 Last updated: 2014-05-16Bibliographically approved
List of papers
1. Reflectometry, ablation and fluid retrieval with an optical fiber
Open this publication in new window or tab >>Reflectometry, ablation and fluid retrieval with an optical fiber
2010 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 18, no 1, 134-140 p.Article in journal (Refereed) Published
Abstract [en]

A technique combining low-coherence reflectometry, laser ablation and microfluidics in a single microstructured fiber is developed. Experimental results demonstrate the possibility to ablate thin aluminum foil samples with fiber-guided Nd:YAG laser light, to collect liquid in the holes of the fiber and to simultaneously monitor the positioning of fiber for ablation and the fluid collection process with low-coherence reflectometry. Potential applications of the technique include minimally invasive retrieval of liquid samples with low contamination risk.

Keyword
coherence tomography, tissue ablation, laser-ablation
National Category
Atom and Molecular Physics and Optics
Identifiers
urn:nbn:se:kth:diva-19099 (URN)10.1364/OE.18.000134 (DOI)000273249400018 ()2-s2.0-73549094703 (Scopus ID)
Funder
Swedish Research Council
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved
2. Increased sensitivity in fiber-based spectroscopy using carbon-coated fiber
Open this publication in new window or tab >>Increased sensitivity in fiber-based spectroscopy using carbon-coated fiber
2012 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 20, no 27, 28049-28055 p.Article in journal (Refereed) Published
Abstract [en]

Carbon-coated optical fibers are used here for reducing the luminescence background created by the primary-coating and thus increase the sensitivity of fiber-based spectroscopy systems. The 2-3 orders of magnitude signal-to-noise ratio improvement with standard telecom fibers is sufficient to allow for their use as Raman probes in the identification of organic solvents.

Keyword
Raman Probe Designs, Optical-Fibers, Silica Fibers, Luminescence
National Category
Engineering and Technology
Identifiers
urn:nbn:se:kth:diva-116811 (URN)10.1364/OE.20.028049 (DOI)000314911400010 ()2-s2.0-84872032750 (Scopus ID)
Funder
Swedish Research Council
Note

QC 20130129

Available from: 2013-01-29 Created: 2013-01-28 Last updated: 2017-12-06Bibliographically approved
3. All-Fiber Optofluidic Component to Combine Light and Fluid
Open this publication in new window or tab >>All-Fiber Optofluidic Component to Combine Light and Fluid
2014 (English)In: IEEE Photonics Technology Letters, ISSN 1041-1135, E-ISSN 1941-0174, Vol. 26, no 10, 1031-1033 p.Article in journal (Refereed) Published
Abstract [en]

A component is presented that combines light and fluid in an optical fiber arrangement for optofluidics. The component couples light from a standard telecom fiber (STF) to the solid-core of a microstructured fiber, and delivers fluid from a capillary to the holes of the same microstructured fiber. The light is then made to interact longitudinally with the delivered fluid in a hollow-core fiber or capillary. The component is all-spliced, hermetic and allows for fluid flow without interrupting the optical beam. Light is brought from the STF to the solid-core/fluid interface with a loss <0.1 dB.

Keyword
Optical fibers, optical waveguide components, optical fiber coupling, fluidics
National Category
Other Physics Topics
Identifiers
urn:nbn:se:kth:diva-145313 (URN)10.1109/LPT.2014.2312483 (DOI)000335563300001 ()2-s2.0-84900033588 (Scopus ID)
Funder
Swedish Research Council
Note

QC 20140514

Available from: 2014-05-15 Created: 2014-05-15 Last updated: 2017-12-05Bibliographically approved
4. A fiber optic system for detection and collection of micrometer-size particles
Open this publication in new window or tab >>A fiber optic system for detection and collection of micrometer-size particles
Show others...
2014 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 22, no 18, 21480-21487 p.Article in journal (Refereed) Published
Abstract [en]

An optical fiber containing longitudinal holes adjacent to the core has been used to detect and collect fluorescent particles from a solution. Excitation light was launched through the fiber and fluorescence signal was guided back to a detector system. As a proof of principle, green and red fluorescent polystyrene beads were detected and selectively collected from a water solution containing a mixture of red and green fluorescent beads.

National Category
Other Physics Topics
Identifiers
urn:nbn:se:kth:diva-145318 (URN)10.1364/OE.22.021480 (DOI)000341428000033 ()2-s2.0-84907284431 (Scopus ID)
Note

Updated from submitted to published.

QC 20141003

Available from: 2014-05-15 Created: 2014-05-15 Last updated: 2017-12-05Bibliographically approved

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