Birth characteristics in a clinical sample of women seeking infertility treatment: a case-control study
2014 (English)In: BMJ Open, ISSN 2044-6055, Vol. 4, no 3, 004197- p.Article in journal (Refereed) Published
Objective To determine the distribution of low birth weight (LBW), preterm birth, small for gestational age (SGA) and large for gestational age (LGA) by main cause of infertility (female, combined, male, unexplained) in women seeking infertility treatment. Design A case-control study. Setting A Centre for Reproductive Medicine in Sweden. Participants All women (n=1293) born in Sweden in 1973 or later and who were part of heterosexual couples seeking infertility treatment at a Centre of Reproductive Medicine from 2005 to 2010 were asked to participate. Those who had not begun the diagnostic process and who declined participation in the study were excluded. In total, 1206 women (94.5%) participated in the study. Main outcome measures Main cause of infertility (female, combined, male, unexplained) collected from the patients medical charts. LBW (less than 2500 g), preterm birth (less than 37 weeks), SGA (less than-2SD of the mean weight for the gestational length) and LGA (greater than+2SD of the mean weight for the gestational length), collected from the Swedish Medical Birth Register. Results The risk of being born with LBW was increased about 2.4 times (OR=2.40, CI 1.13 to 5.07, p=0.02) in women seeking treatment for infertility due to female causes rather than for male or unexplained causes. Women with a female infertility factor were 2.7 times more likely to be born SGA (OR=2.73, CI 1.02 to 7.34, p=0.047) compared with those in whom the cause of infertility was unexplained. Conclusions Women born with LBW or SGA seem to suffer an increased risk of infertility due to a female factor. Thus, infants born with birth characteristics that deviate from the norm may be at greater risk of difficulties in childbearing later on in life. Since this study is the first of its kind, more studies are needed to verify the associations found in this study and to determine their nature.
Place, publisher, year, edition, pages
BMJ Publishing Group: BMJ Open / BMJ Journals , 2014. Vol. 4, no 3, 004197- p.
Small for Gestational age; In Vitro Fertilization; Preterm Birth; Low Birth Weight; Infertility; Very Low Birth Weight
Obstetrics, Gynecology and Reproductive Medicine
IdentifiersURN: urn:nbn:se:liu:diva-106526DOI: 10.1136/bmjopen-2013-004197ISI: 000333921300084OAI: oai:DiVA.org:liu-106526DiVA: diva2:716610