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Thermodynamics of fenofibrate and solubility in pure organic solvents
KTH, School of Chemical Science and Engineering (CHE), Chemical Engineering and Technology, Transport Phenomena. SSPC, University of Limerick, Ireland.ORCID iD: 0000-0002-6647-3308
KTH, School of Chemical Science and Engineering (CHE), Chemical Engineering and Technology, Transport Phenomena. University of Limerick, Ireland.
2014 (English)In: Fluid Phase Equilibria, ISSN 0378-3812, E-ISSN 1879-0224, Vol. 367, 143-150 p.Article in journal (Refereed) Published
Abstract [en]

Calorimetric data on the melting of 1-methylethyl 2-[4-(4-chlorobenzoyl)-phenoxyl-2-methylpropanoate (fenofibrate) and the heat capacity of the solid and the melt have been determined, from which the Gibbs energy, enthalpy and entropy of fusion are calculated. Solid-liquid solubility data have been collected by a gravimetric method in seven pure solvents (methanol, ethanol, 1-propanol, 2-propanol, ethyl acetate, acetonitrile, and acetone) across a range of temperatures. Fenofibrate is much more soluble in ethyl acetate, acetonitrile and acetone compared to alcohols. In the alcohols the solubility increases with aliphatic chain length. The Gibbs energy of fusion is used to estimate the activity of the solid within a Raoult's law framework. Except for ethyl acetate solutions which are almost ideal, solutions in all evaluated solvents exhibit positive deviation from Raoult's law, and in the alcohols the activity coefficient ranges up to 25. It is shown that the heat capacity component of the enthalpy of fusion is not negligible at room temperature, in spite of the proximity to the melting point, and furthermore that the temperature dependence of the activity coefficient in the saturated solution has a governing influence on the van't Hoff enthalpy of solution in acetonitrile and the alcohols. Crystals obtained by two different methods from a range of solvents have been analysed by PXRD, FTIR and NMR spectroscopy, TGA and DSC, and have in all cases been shown to consist of the stable polymorph (form l).

Place, publisher, year, edition, pages
2014. Vol. 367, 143-150 p.
Keyword [en]
Crystallisation, Thermodynamics, Solubility, Activity coefficient, Heat capacity
National Category
Other Chemical Engineering
URN: urn:nbn:se:kth:diva-145085DOI: 10.1016/j.fluid.2014.01.029ISI: 000334003400020ScopusID: 2-s2.0-84894307133OAI: diva2:716313
Swedish Research Council, 621-2010-5391

QC 20140509

Available from: 2014-05-09 Created: 2014-05-08 Last updated: 2016-10-26Bibliographically approved

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