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Aerosol sampling using an electrostatic precipitator integrated with a microfluidic interface
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9177-1174
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-6915-257X
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-6443-878X
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
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2015 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 212, 344-352 p.Article in journal (Refereed) Published
Abstract [en]

In this work, the development of a point-of-care (PoC) system to capture aerosol from litres of air directly onto a microfluidic lab-on-chip for subsequent analysis is addressed. The system involves an electrostatic precipitator that uses corona charging and electrophoretic transport to capture aerosol droplets onto a microfluidic air-to-liquid interface for downstream analysis. A theoretical study of the governing geometric and operational parameters for optimal electrostatic precipitation is presented. The fabrication of an electrostatic precipitator prototype and its experimental validation using a laboratory-generated aerosolized dye is described. Collection efficiencies were comparable to those of a state-of-the-art Biosampler impinger, with the significant advantage of providing samples that are at least 10 times more concentrated. Finally, we discuss the potential of such a system for breath-based diagnostics.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 212, 344-352 p.
Keyword [en]
breath analysis, poc, point-of-care, lab-on-chip, loc, microfluidics, aerosol, sampling, medical device, diagnostics, electrostatic precipitation, corona discharge
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering Other Medical Biotechnology
Research subject
Electrical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-144986DOI: 10.1016/j.snb.2015.02.008ISI: 000351017700043Scopus ID: 2-s2.0-84923763722OAI: oai:DiVA.org:kth-144986DiVA: diva2:715441
Projects
Rappid
Note

QC 20150223

Available from: 2014-05-05 Created: 2014-05-05 Last updated: 2017-12-05Bibliographically approved
In thesis
1. From Macro to Nano: Electrokinetic Transport and Surface Control
Open this publication in new window or tab >>From Macro to Nano: Electrokinetic Transport and Surface Control
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Today, the growing and aging population, and the rise of new global threats on human health puts an increasing demand on the healthcare system and calls for preventive actions. To make existing medical treatments more efficient and widely accessible and to prevent the emergence of new threats such as drug-resistant bacteria, improved diagnostic technologies are needed. Potential solutions to address these medical challenges could come from the development of novel lab-on-chip (LoC) for point-of-care (PoC) diagnostics.

At the same time, the increasing demand for sustainable energy calls for the development of novel approaches for energy conversion and storage systems (ECS), to which micro- and nanotechnologies could also contribute.

This thesis has for objective to contribute to these developments and presents the results of interdisciplinary research at the crossing of three disciplines of physics and engineering: electrokinetic transport in fluids, manufacturing of micro- and nanofluidic systems, and surface control and modification. By combining knowledge from each of these disciplines, novel solutions and functionalities were developed at the macro-, micro- and nanoscale, towards applications in PoC diagnostics and ECS systems.

At the macroscale, electrokinetic transport was applied to the development of a novel PoC sampler for the efficient capture of exhaled breath aerosol onto a microfluidic platform.

At the microscale, several methods for polymer micromanufacturing and surface modification were developed. Using direct photolithography in off-stoichiometry thiol-ene (OSTE) polymers, a novel manufacturing method for mold-free rapid prototyping of microfluidic devices was developed. An investigation of the photolithography of OSTE polymers revealed that a novel photopatterning mechanism arises from the off-stoichiometric polymer formulation. Using photografting on OSTE surfaces, a novel surface modification method was developed for the photopatterning of the surface energy. Finally, a novel method was developed for single-step microstructuring and micropatterning of surface energy, using a molecular self-alignment process resulting in spontaneous mimicking, in the replica, of the surface energy of the mold.

At the nanoscale, several solutions for the study of electrokinetic transport toward selective biofiltration and energy conversion were developed. A novel, comprehensive model was developed for electrostatic gating of the electrokinetic transport in nanofluidics. A novel method for the manufacturing of electrostatically-gated nanofluidic membranes was developed, using atomic layer deposition (ALD) in deep anodic alumina oxide (AAO) nanopores. Finally, a preliminary investigation of the nanopatterning of OSTE polymers was performed for the manufacturing of polymer nanofluidic devices.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2014. xix, 113 p.
Series
TRITA-EE, ISSN 1653-5146 ; 2014:020Theses in philosophy from the Royal Institute of Technology, ISSN 1650-8831
Keyword
microsystem, nanosystem, microfluidic, nanofluidic, surface modification, surface property, electrokinetics, model, simulation, material, polymer, thiol-ene, microfabrication, nanofabrication, micromanufacturing, nanomanufacturing, breath sampling, aerosol precipitation, corona discharge, electrostatic precipitation, grafting chemistry, click chemistry, nanopore, nanoporous membrane, photolithography, photopatterning, photografting, microfluidics, nanofluidics, oste, OSTE+, OSTEmer, lab-on-chip, loc, point-of-care, poc, biocompatibility, diagnostics, breath analysis, fuel cell
National Category
Nano Technology Other Electrical Engineering, Electronic Engineering, Information Engineering Textile, Rubber and Polymeric Materials Other Medical Engineering Polymer Technologies
Research subject
Electrical Engineering; Materials Science and Engineering; Physics; Medical Technology
Identifiers
urn:nbn:se:kth:diva-144994 (URN)978-91-7595-119-5 (ISBN)
Public defence
2014-05-23, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:00 (English)
Opponent
Supervisors
Projects
RappidNanoGateNorosensor
Funder
Swedish Research CouncilEU, European Research Council
Note

QC 20140509

Available from: 2014-05-09 Created: 2014-05-05 Last updated: 2014-12-04Bibliographically approved
2. Integrating Biosensors for Air Monitoring and Breath-Based Diagnostics
Open this publication in new window or tab >>Integrating Biosensors for Air Monitoring and Breath-Based Diagnostics
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The air we breathe is the concern of all of us but nevertheless we only know very little about airborne particles, and especially which biological microorganisms they contain. Today, we live in densely populated societies with a growing number of people, making us particularly vulnerable to air transmission of pathogens. With the recent appearance of highly pathogenic types of avian influenza in southeast Asia and the seasonal outbreaks of gastroenteritis caused by the extremely contagious norovirus, the need for portable, sensitive and rapid instruments for on-site detection and monitoring of airborne pathogens is apparent.

Unfortunately, the integration incompatibility between state-of-the-art air sampling techniques and laboratory based analysis methods makes instruments for in-the-field rapid detection of airborne particles an unresolved challenge.

This thesis aims at addressing this challenge by the development of novel manufacturing, integration and sampling techniques to enable the use of label-free biosensors for rapid and sensitive analysis of airborne particles at the point-of-care or in the field.

The first part of the thesis introduces a novel reaction injection molding technique for the fabrication of high quality microfluidic cartridges. In addition, electrically controlled liquid aspiration and dispensing is presented, based on the use of a thermally actuated polymer composite integrated with microfluidic cartridges.

The second part of the thesis demonstrates three different approaches of biosensor integration with microfluidic cartridges, with a focus on simplifying the design and integration to enable disposable use of the cartridges.

The third part to the thesis presents a novel air sampling technique based on electrophoretic transport of airborne particles directly to microfluidic cartridges. This technique is enabled by the development of a novel microstructured component for integrated air-liquid interfacing. In addition, a method for liquid sample mixing with magnetic microbeads prior to downstream biosensing is demonstrated.In the fourth part of the thesis, three different applications for airborne particle biosensing are introduced and preliminary experimental results are presented.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2015. xix, 85 p.
Series
TRITA-EE, ISSN 1653-5146 ; 2015:020
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-165454 (URN)978-91-7595-560-5 (ISBN)
Public defence
2015-05-22, Q2, Osquldas väg 10, KTH, Stockholm, 10:00 (English)
Opponent
Supervisors
Projects
RPARappidNorosensor
Funder
EU, FP7, Seventh Framework ProgrammeVINNOVASwedish Research CouncilSwedish Foundation for Strategic Research
Note

QC 20150429

Available from: 2015-04-29 Created: 2015-04-28 Last updated: 2015-04-29Bibliographically approved

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