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Reprogramming and Carcinogenesis-Parallels and Distinctions
Karolinska Institute, Stockholm, Sweden.
Pomeranian Medical University, Szczecin, Poland.
University of Belgrade, Serbia.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. Silesian Technical University, Gliwice, Poland.
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2014 (English)In: International Review of Cell and Molecular Biology / [ed] Kwang W Jeon, Elsevier, 2014, Vol. 308, 167-203 p.Chapter in book (Refereed)
Abstract [en]

Rapid progress made in various areas of regenerative medicine in recent years occurred both at the cellular level, with the Nobel prize-winning discovery of reprogramming (generation of induced pluripotent stem (iPS) cells) and also at the biomaterial level. The use of four transcription factors, Oct3/4, Sox2, c-Myc, and Klf4 (called commonly "Yamanaka factors") for the conversion of differentiated cells, back to the pluripotent/embryonic stage, has opened virtually endless and ethically acceptable source of stem cells for medical use. Various types of stem cells are becoming increasingly popular as starting components for the development of replacement tissues, or artificial organs. Interestingly, many of the transcription factors, key to the maintenance of stemness phenotype in various cells, are also overexpressed in cancer (stem) cells, and some of them may find the use as prognostic factors. In this review, we describe various methods of iPS creation, followed by overview of factors known to interfere with the efficiency of reprogramming. Next, we discuss similarities between cancer stem cells and various stem cell types. Final paragraphs are dedicated to interaction of biomaterials with tissues, various adverse reactions generated as a result of such interactions, and measures available, that allow for mitigation of such negative effects.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 308, 167-203 p.
, International Review of Cell and Molecular Biology, ISSN 1937-6448 ; 308
Keyword [en]
Bioglass, Senescence, Transdifferentiation, Yamanaka factor, iPS cells, p53
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-106107DOI: 10.1016/B978-0-12-800097-7.00005-1ISI: 000333378100005ISBN: 978-0-12-800097-7OAI: diva2:714172
Available from: 2014-04-25 Created: 2014-04-24 Last updated: 2014-10-08Bibliographically approved

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Cieslar-Pobuda, ArturRafat, MehrdadLos, Marek Jan
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