Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
On the Modelling of Kainate Receptor Channels
KTH, School of Engineering Sciences (SCI), Mathematics (Dept.), Mathematics (Div.).
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Kainate receptor channels are a class of ion channels found on the membrane of nerve cells. These proteins play a key role in the brain, since their properties regulate the strength of the synapses. Their structure and gating mechanisms are still extensively studied by biologists: originally closed, the channel opens upon the binding of kainate, allowing ions to flow inside the cell through the pores and creating thus an electrical current. It undergoes then a desensitization: the channel is closed even if the kainite is still bound.

In this Master's Thesis, we put forward a mathematical model that reproduces both qualitatively and quantitatively the observed behaviours of kainate receptor channels. The distinctive feature of the model lies in its original framework ANC, which uses rule-based formalism to model allosteric proteins. We find that compared to traditional kinetic scheme, our model has the advantage of being scalable.

We propose furthermore an alternative model. It includes a new hypothesis, namely that the ions that flow through the channel alter its gating properties. We illustrate the modularity of ANC, which enables a straightforward definition of the new model from the former, and an easy switch between these two. Our results suggest finally that this new model agrees with the biological observed behaviours of the channels.

Place, publisher, year, edition, pages
2014.
Series
TRITA-MAT-E ; 2014:24
National Category
Mathematics
Identifiers
URN: urn:nbn:se:kth:diva-144106OAI: oai:DiVA.org:kth-144106DiVA, id: diva2:711192
External cooperation
Imperial College London
Subject / course
Mathematics
Educational program
Master of Science in Engineering -Engineering Physics
Supervisors
Examiners
Available from: 2014-04-09 Created: 2014-04-09 Last updated: 2014-04-09Bibliographically approved

Open Access in DiVA

fulltext(1130 kB)225 downloads
File information
File name FULLTEXT01.pdfFile size 1130 kBChecksum SHA-512
7c9ba3cc174314d0406f76bf0edb094f0bf7648d30ef431e4b582fdc7dee0bc350bc76cc811c7dd946227e39d0ba41b541c32e292f1532b017555511e5fb918f
Type fulltextMimetype application/pdf

By organisation
Mathematics (Div.)
Mathematics

Search outside of DiVA

GoogleGoogle Scholar
Total: 225 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 104 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf