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Mutations in Toll-Like Receptor 3 Are Associated with Elevated Levels of Rotavirus-Specific IgG Antibodies in IgA-Deficient but Not IgA-Sufficient Individuals
Karolinska University Hospital, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
Karolinska University Hospital, Sweden .
2014 (English)In: Clinical and Vaccine Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 21, no 3, 298-301 p.Article in journal (Refereed) Published
Abstract [en]

Double-stranded RNA (dsRNA) triggers immune-mediated responses through toll-like receptor 3 (TLR3), which is involved in innate antiviral defense. Low expression of TLR3 was recently suggested to contribute to susceptibility to rotavirus infection. Thus, we investigated the role of two TLR3 polymorphisms (rs3775291 and rs5743305), both of which resulted in reduced protein function or expression, in healthy blood donors and IgA-deficient (IgAD) individuals. These polymorphisms were associated with elevated rotavirus-specific IgG titers in IgAD individuals but not in healthy individuals. Thus, we propose that TLR3 signaling does not contribute to the rotavirus-specific antibody response in IgA-sufficient individuals, whereas it is associated with elevated antibody titers in IgAD individuals.

Place, publisher, year, edition, pages
American Society for Microbiology , 2014. Vol. 21, no 3, 298-301 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-105572DOI: 10.1128/CVI.00666-13ISI: 000332036900005OAI: oai:DiVA.org:liu-105572DiVA: diva2:708866
Available from: 2014-03-31 Created: 2014-03-27 Last updated: 2017-10-31

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