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Genes Involved in Epithelial Differentiation and Development are Differentially Expressed in Oral and Genital Lichen Planus Epithelium Compared to Normal Epithelium
Umeå University, Faculty of Medicine, Department of Medical Biosciences.
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology, School of Dentistry.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
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2014 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 94, no 5, 526-530 p.Article in journal (Refereed) Published
Abstract [en]

Lichen planus (LP) is a chronic mucocutaneous disease with unknown cause. Patients with LP often have both oral and genital lesions, but these conditions are often considered as separate diseases and treated accordingly. To find out which genes are differently expressed in mucosal LP compared to normal mucosa and establish whether oral and genital LP are in fact the same disease, whole genome expression analysis was performed on epithelium from 13 patients diagnosed with oral and/or genital LP and normal controls. For confirmation of keratin 4 and corneodesmosin expression, quantitative reverse-transcription PCR and immunohistochemistry were used. Many genes involved in epithelial development and differentiation are differently expressed in epithelium from LP compared to normal epithelium. Several of the differentially expressed genes are common for oral and genital LP and the same biological processes are altered which supports the fact that oral and genital LP are manifestations of the same disease. The change in gene expression indicates that differentiation is altered leading to changes in the epithelial barrier.

Place, publisher, year, edition, pages
2014. Vol. 94, no 5, 526-530 p.
Keyword [en]
oral lichen planus, genital lichen planus, epithelial differentiation, corneodesmosin, keratin 4
National Category
Cell and Molecular Biology Medical Genetics
URN: urn:nbn:se:umu:diva-87232DOI: 10.2340/00015555-1803ISI: 000341676400006PubMedID: 24626344OAI: diva2:707707
Available from: 2014-03-25 Created: 2014-03-25 Last updated: 2014-11-05Bibliographically approved

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Danielsson, KarinCoates, Philip JEbrahimi, MajidNylander, ElisabetWahlin, Ylva-BrittNylander, Karin
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Department of Medical BiosciencesDepartment of OdontologySchool of DentistryDermatology and VenerologyPathology
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