Change search
ReferencesLink to record
Permanent link

Direct link
Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis
Show others and affiliations
2013 (English)In: Arthritis Research & Therapy, ISSN 1478-6362, Vol. 15, no 4, R83- p.Article in journal (Refereed) Published
Abstract [en]

Introduction: This randomized, controlled study on patients with polymyositis or dermatomyositis was based on three hypotheses: patients display impaired endurance due to reduced aerobic capacity and muscle weakness, endurance training improves their exercise performance by increasing the aerobic capacity, and endurance training has general beneficial effects on their health status. Methods: In the first part of this study, we compared 23 patients with polymyositis or dermatomyositis with 12 age-and gender-matched healthy controls. A subgroup of patients were randomized to perform a 12-week endurance training program (exercise group, n = 9) or to a non-exercising control group (n = 6). We measured maximal oxygen uptake (VO2 max) and the associated power output during a progressive cycling test. Endurance was assessed as the cycling time to exhaustion at 65% of VO2 max. Lactate levels in the vastus lateralis muscle were measured with microdialysis. Mitochondrial function was assessed by measuring citrate synthase (CS) and beta-hydroxyacyl-CoA dehydrogenase (beta-HAD) activities in muscle biopsies. Clinical improvement was assessed according to the International Myositis Assessment and Clinical Studies Group (IMACS) improvement criteria. All assessors were blinded to the type of intervention (that is, training or control). Results: Exercise performance and aerobic capacity were lower in patients than in healthy controls, whereas lactate levels at exhaustion were similar. Patients in the exercise group increased their cycling time, aerobic capacity and CS and beta-HAD activities, whereas lactate levels at exhaustion decreased. Six of nine patients in the exercise group met the IMACS improvement criteria. Patients in the control group did not show any consistent changes during the 12-week study. Conclusions: Polymyositis and dermatomyositis patients have impaired endurance, which could be improved by 12 weeks of endurance training. The clinical improvement corresponds to increases in aerobic capacity and muscle mitochondrial enzyme activities. The results emphasize the importance of endurance exercise in addition to immunosuppressive treatment of patients with polymyositis or dermatomyositis.

Place, publisher, year, edition, pages
2013. Vol. 15, no 4, R83- p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-220568DOI: 10.1186/ar4263ISI: 000330628300013OAI: oai:DiVA.org:uu-220568DiVA: diva2:706376
Available from: 2014-03-20 Created: 2014-03-17 Last updated: 2014-03-20Bibliographically approved

Open Access in DiVA

fulltext(547 kB)246 downloads
File information
File name FULLTEXT01.pdfFile size 547 kBChecksum SHA-512
b6fbdf826733d6f02fecbffdfae91967deb4f141ae239756d988f58604b670703fd157866a0e1364b5199a3f781e823ecead79d3f91eeaf27884178dd1cdd848
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Lidén, Maria
By organisation
Rheumatology
In the same journal
Arthritis Research & Therapy
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 246 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 239 hits
ReferencesLink to record
Permanent link

Direct link