Change search
ReferencesLink to record
Permanent link

Direct link
Neopterin is associated with cardiovascular events and all-cause mortality in renal transplant patients
Show others and affiliations
2014 (English)In: Clinical Transplantation, ISSN 0902-0063, E-ISSN 1399-0012, Vol. 28, no 1, 111-119 p.Article in journal (Refereed) Published
Abstract [en]

BackgroundInflammatory markers show significant associations with cardiovascular events and all-cause mortality after kidney transplantation. Neopterin, reflecting interferon--release, may better reflect the proinflammatory state of recipients than less specific markers. MethodsKidney transplant recipients in the Assessment of LEscol in Renal Transplant (ALERT) trial were examined and investigated for an association between serum neopterin and subsequent clinical events: graft loss, major cardiovascular events (MACE) and all-cause mortality. ResultsAfter adjustment for established and emerging risk factors neopterin expressed as neopterin-to-creatinine ratio was significantly associated with MACE (p=0.009) and all-cause mortality (p=0.002). Endpoints were more frequent with increasing quartiles of neopterin-to-creatinine ratio. The incidence rates of MACE and all-cause mortality were significantly increased in the upper quartiles compared with the first. ConclusionsThis long-term prospective analysis in stable kidney allograft recipients suggests that neopterin is associated with long-term risk of cardiovascular events and all-cause mortality, but not renal outcomes.

Place, publisher, year, edition, pages
2014. Vol. 28, no 1, 111-119 p.
Keyword [en]
inflammatory marker, kidney transplantation, long-term, neopterin, outcomes
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-220310DOI: 10.1111/ctr.12285ISI: 000330641200015OAI: diva2:705502
Available from: 2014-03-17 Created: 2014-03-12 Last updated: 2014-03-17Bibliographically approved

Open Access in DiVA

fulltext(158 kB)84 downloads
File information
File name FULLTEXT01.pdfFile size 158 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Fellström, Bengt
By organisation
Renal Medicine
In the same journal
Clinical Transplantation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 84 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 197 hits
ReferencesLink to record
Permanent link

Direct link