Change search
ReferencesLink to record
Permanent link

Direct link
Interobserver Variability of Histopathological Prognostic Parameters in Cutaneous Malignant Melanoma: Impact on Patient Management
Show others and affiliations
2013 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 93, no 4, 411-416 p.Article in journal (Refereed) Published
Abstract [en]

Clinical management of primary cutaneous melanomas is based on histopathological staging of the tumour. The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of the evaluation of histopathological prognostic parameters in cutaneous malignant melanomas, and to what extent the putative variability affected clinical management. A total of 234 cases of invasive cutaneous malignant melanoma were included in the study from the Stockholm-Gotland Healthcare Region in Sweden. Overall interobserver variability between a general pathologist and an expert review was 68.8-84.8%. Approximately 15.5% of melanomas <= 1 mm were re-classified either as melanoma in situ or melanomas >1 mm after review. In conclusion, review by a pathologist experienced in melanoma resulted in a change in recommendations about surgical excision margins and/or sentinel node biopsy in subgroups of Ti melanomas.

Place, publisher, year, edition, pages
2013. Vol. 93, no 4, 411-416 p.
Keyword [en]
melanoma, pathology, prognosis, interobserver, variability, treatment
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-219890DOI: 10.2340/00015555-1517ISI: 000330421700005OAI: diva2:703423
Available from: 2014-03-06 Created: 2014-03-06 Last updated: 2014-03-06Bibliographically approved

Open Access in DiVA

fulltext(231 kB)80 downloads
File information
File name FULLTEXT01.pdfFile size 231 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Lundh Rozell, Barbro
By organisation
Molecular and Morphological Pathology
In the same journal
Acta Dermato-Venereologica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 80 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 177 hits
ReferencesLink to record
Permanent link

Direct link