Change search
ReferencesLink to record
Permanent link

Direct link
Threshold of Toxicological Concern (TTC): Literature review and applicability
Responsible organisation
2005 (English)Book (Other academic)
Abstract [en]

In the regulation of food contact articles and flavouring substances, the TTC concept (Threshold of Toxicological Concern) has been developed as a substitute for substance-specific information. The TTC concept is based on the analysis of the toxicological and/or structural data of a broad range of different chemicals, with the aim to set an exposure-value below which no toxicity testing is necessary. Recently, application of the TTC concept has been proposed as a tool in risk assessment of industrial chemicals within REACH, both for defining when no testing is needed based on exposure information and as a substitute for effect values. The proposal concerns both human health and the environment. The present report does not advocate the use of TTC instead of substance specific toxicity data for risk assessment of industrial chemicals within REACH at time being. This conclusion is based on current knowledge and understanding of the concept, and on limitations and uncertainties in the derivation of TTCs. Furthermore, the suitability of the TTC concept so far has not been evaluated for the diverse group of industrial chemicals. In addition, the possible consequences for the level of protection of human health and the environment resulting from applying the TTC concept in the risk assessment should be examined.

Place, publisher, year, edition, pages
Copenhagen: Nordic Council of Ministers , 2005. , 53 p.
TemaNord, ISSN 0908-6692 ; 2005:559
Keyword [fi]
kemikaalit, elintarvikkeet, ympäristö
Keyword [da]
Kemikalier, Fødevarer, Miljø
Keyword [is]
Efni, Matvæli, Umhverfi
Keyword [no]
Kjemikalier, Næringsmidler, Miljø
Research subject
Chemicals; Food; Environment
URN: urn:nbn:se:norden:org:diva-2324DOI: 10.6027/TN2005-559ISBN: 92-893-1196-7OAI: diva2:702709
Available from: 2014-03-04 Created: 2014-03-04 Last updated: 2014-09-05

Open Access in DiVA

fulltext(557 kB)52 downloads
File information
File name FULLTEXT01.pdfFile size 557 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search outside of DiVA

GoogleGoogle Scholar
Total: 52 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 435 hits
ReferencesLink to record
Permanent link

Direct link