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Development of a test bench for Gamma Knife Optimization
KTH, School of Engineering Sciences (SCI), Mathematics (Dept.), Optimization and Systems Theory.
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The dose distribution in the Gamma Knife (developed and produced by Elekta) is optimized over the weights (or Beam-on time) using different models other than the radiosurgical one used in Leksell Gamma Plan . These are based on DVH, EUD, TCP and NTCP. Also adding hypoxic regions are tested in the Gamma Knife to see whether or not the dose can be guided to these areas. This is done in two ways. For the DVH and EUD model the hypoxic area is regarded as a organ by itself and higher constraints is defined on it. In the TCP case blood vessels are outlined and the α and β parameters are perturbed to describe a hypoxic area. The models are tested in two cases. The first one is one tumour close to the brainstem and the second case is two tumours located far away from each other. Finally the results are compared to the dose distribution computed by the Gamma Knife.


Place, publisher, year, edition, pages
TRITA-MAT-E, 2014:02
National Category
URN: urn:nbn:se:kth:diva-140218OAI: diva2:699782
Subject / course
Optimization and Systems Theory
Educational program
Master of Science - Mathematics
Available from: 2014-02-28 Created: 2014-01-18 Last updated: 2014-02-28Bibliographically approved

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