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Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada .
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada .
Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, Ontario, Canada .
2010 (English)In: Materials, ISSN 1996-1944, Vol. 3, no 6, 3714-3728 p.Article in journal (Refereed) Published
Abstract [en]

Studies using cellular therapies, scaffolds, and tubular structured implants have been carried out with the goal to restore functional recovery after spinal cord injury (SCI). None of these therapeutic strategies, by themselves, have been shown to be sufficient to achieve complete restoration of function. To reverse the devastating effects of SCI, an interdisciplinary approach that combines materials science and engineering, stem cell biology, and neurosurgery is being carried out. We are currently investigating a scaffold that has the ability to deliver growth factors for the proliferation and differentiation of endogenous stem cells. Neural stem cells (NSCs) derived from mice are being used to assess the efficacy of the release of growth factors from the scaffold in vitro. The fabrication of the tubular implant allows a porous scaffold to be formed, which aids in the release of growth factors added to the scaffold.

Place, publisher, year, edition, pages
Basel, Switzerland: MDPI AG , 2010. Vol. 3, no 6, 3714-3728 p.
Keyword [en]
neurospheres, nerve tissue engineering, electrospun nanofibers, differentiation
National Category
Materials Engineering
URN: urn:nbn:se:liu:diva-103164DOI: 10.3390/ma3063714ISI: 000298241700012OAI: diva2:687404
Available from: 2014-01-14 Created: 2014-01-14 Last updated: 2014-09-25Bibliographically approved

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Hackett, Joanne M.
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