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The Resveratrol Tetramer (-)-Hopeaphenol Inhibits Type III Secretion in the Gram-Negative Pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). (Mikael Elofsson)
Creative Antibiotics Sweden AB, Umeå, Sweden .
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Eskitis Institute, Griffith University, Brisbane, Australia.
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2013 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 8, no 12, e81969- p.Article in journal (Refereed) Published
Abstract [en]

Society faces huge challenges, as a large number of bacteria have developed resistance towards many or all of the antibiotics currently available. Novel strategies that can help solve this problem are urgently needed. One such strategy is to target bacterial virulence, the ability to cause disease e.g., by inhibition of type III secretion systems (T3SSs) utilized by many clinically relevant gram-negative pathogens. Many of the antibiotics used today originate from natural sources. In contrast, most virulence-blocking compounds towards the T3SS identified so far are small organic molecules. A recent high-throughput screening of a prefractionated natural product library identified the resveratrol tetramer (-)-hopeaphenol as an inhibitor of the T3SS in Yersinia pseudotuberculosis. In this study we have investigated the virulence blocking properties of (-)-hopeaphenol in three different gram-negative bacteria. (-)- Hopeaphenol was found to have micromolar activity towards the T3SSs in Yersinia pseudotuberculosis and Pseudomonas aeruginosa in cell-based infection models. In addition (-)-hopeaphenol reduced cell entry and subsequent intracellular growth of Chlamydia trachomatis.

Place, publisher, year, edition, pages
PloS ONE , 2013. Vol. 8, no 12, e81969- p.
National Category
Chemical Sciences
URN: urn:nbn:se:umu:diva-84598DOI: 10.1371/journal.pone.0081969OAI: diva2:685921
Swedish Research Council
Available from: 2014-01-10 Created: 2014-01-10 Last updated: 2014-02-05Bibliographically approved

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Zetterström, Caroline E.Salin, OlliElofsson, Mikael
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