Patch testing with formaldehyde 2.0% in parallel with 1.0% by the Swedish Contact Dermatitis Research Group
2014 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 94, no 4, 408-410 p.Article in journal (Refereed) Published
In a multicentre study consecutively patch-tested dermatitis patients were tested simultaneously with 1.0% and 2.0% (w/v) formaldehyde in aqua applied with a micropipette (15 µl) to the filter paper disc in Finn Chambers (0.30 mg/cm2 and 0.60 mg/cm2, respectively). A total of 2,122 dermatitis patients were patch-tested. In all, 77 (3.6%) patients reacted positively to formaldehyde; 37 reacted only to 2.0%, 35 reacted to both concentrations and 5 patients reacted only to 1.0%. Significantly more patients were thus diagnosed with contact allergy to formaldehyde with 2.0% compared to 1.0% (p < 0.001) without causing more irritant reactions. The detected number of isolated allergic reactions to the 2 formaldehyde-releasers in the Swedish baseline series and not to formaldehyde itself raises the question whether quaternium-15 1.0% and diazolidinyl urea 2.0% should be present in the Swedish baseline series.
Place, publisher, year, edition, pages
2014. Vol. 94, no 4, 408-410 p.
formaldehyde, simultaneous contact allergy, baseline series, micropipette, patch test, dose mg/cm², preservative, formaldehyde releasers
Dermatology and Venereal Diseases
IdentifiersURN: urn:nbn:se:umu:diva-84581DOI: 10.2340/00015555-1748ISI: 000339416100007PubMedID: 24337098OAI: oai:DiVA.org:umu-84581DiVA: diva2:685404