Synthesis of azidoethyl 3,4,6-tri-O-acetyl-α-D-mannopyranoside for future bioconjugation in PET studies
Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Positron emission tomography is a powerful imaging method capable of diagnosing and studyingdiseases at atomic levels. The following thesis involves the synthesis of a 2 -deoxy-2 -[18F]uoro-D-glucose derivative able to participate in click chemisty conjugation. The synthesis involves six stepswith D-mannopyranose as starting material; regioselective acetylation and protection of the hydroxylgroup on C-2 of the monosaccharide, glycosylation with 2-azidoethanol, removal of the selectiveprotecting group and substitution of the hydroxyl group on C-2 with uorine. The potential toconjugate the glycoside to other biomolecules and obtain PET data might have uses in diagnosticaland medicinal chemistry.
Place, publisher, year, edition, pages
2013. , 15 p.
IdentifiersURN: urn:nbn:se:liu:diva-102909ISRN: LITH-IFM-G-EX--13/ 2742--SEOAI: oai:DiVA.org:liu-102909DiVA: diva2:684322
Subject / course