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Synthesis of azidoethyl 3,4,6-tri-O-acetyl-α-D-mannopyranoside for future bioconjugation in PET studies
Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry. Linköping University, The Institute of Technology.
2013 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Positron emission tomography is a powerful imaging method capable of diagnosing and studyingdiseases at atomic levels. The following thesis involves the synthesis of a 2 -deoxy-2 -[18F]uoro-D-glucose derivative able to participate in click chemisty conjugation. The synthesis involves six stepswith D-mannopyranose as starting material; regioselective acetylation and protection of the hydroxylgroup on C-2 of the monosaccharide, glycosylation with 2-azidoethanol, removal of the selectiveprotecting group and substitution of the hydroxyl group on C-2 with uorine. The potential toconjugate the glycoside to other biomolecules and obtain PET data might have uses in diagnosticaland medicinal chemistry.

Place, publisher, year, edition, pages
2013. , 15 p.
National Category
Organic Chemistry
URN: urn:nbn:se:liu:diva-102909ISRN: LITH-IFM-G-EX--13/ 2742--SEOAI: diva2:684322
Subject / course
Organic Chemistry
Available from: 2014-01-08 Created: 2014-01-07 Last updated: 2014-01-08Bibliographically approved

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Willén, Daniel
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Organic ChemistryThe Institute of Technology
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