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Speckle tracking strain estimation of a carotid artery plaque phantom - Validation via sonomicrometry
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0002-2487-7400
Karolinska Institutet. (Department of Molecular Medicine and Surgery)
KU Leuven. (Cardiovascular Imaging & Dynamics)
KU Leuven. (Cardiovascular Imaging & Dynamics)
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2013 (English)In: 2013 IEEE International Ultrasonics Symposium (IUS), IEEE conference proceedings, 2013, , 4 p.1757-1760 p.Conference paper (Refereed)
Abstract [en]

Current clinical ultrasound-based methods for plaque characterization are limited to visual assessment of plaque echogenicity creating demand for quantitative diagnostic tools. Our objective was to validate radial and longitudinal speckle tracking (ST) strain in phantom plaques via sonomicrometry (sono), and to compare the peak plaque and arterial wall strain. Four carotid artery gel-phantoms with a soft wall inclusion, mimicking a vulnerable plaque, were constructed. The phantoms were connected to a programmable pump simulating a carotid flow. Cineloops were acquired using a GE Vivid E9 where radial and longitudinal strain were calculated using a normalized cross-correlation ST algorithm. The region of interest was adjusted according to the plaque size. Sonomicrometry was used as a reference measurement. The correlation between estimated mean peak strain and the reference peak strain was r = 0.96 (p < 0.001) radially and r = 0.75 (p ≤ 0.005) longitudinally. The soft plaque exhibited 35.1% (SD 16.9%) greater radial (p < 0.001) and 88.6% (SD 72.0%) greater longitudinal (p < 0.001) peak strain than the arterial wall when measured with speckle tracking. It was possible to estimate plaque strain by ST and to distinguish a soft plaque from the vessel wall via strain measurements.

Place, publisher, year, edition, pages
IEEE conference proceedings, 2013. , 4 p.1757-1760 p.
, IEEE International Ultrasonics Symposium, IUS, ISSN 1948-5719
Keyword [en]
Ultrasound, Speckle Tracking, Plaque, Strain, Phantom, Sonomicrometry, Carotid Artery
National Category
Medical Image Processing
URN: urn:nbn:se:kth:diva-137662DOI: 10.1109/ULTSYM.2013.0448ISI: 000336665300447ScopusID: 2-s2.0-84894308986ISBN: 978-1-4673-5684-8OAI: diva2:679433
2013 IEEE International Ultrasonics Symposium, IUS 2013; Prague; Czech Republic; 21 July 2013 through 25 July 2013

QC 20140103

Available from: 2013-12-16 Created: 2013-12-16 Last updated: 2014-06-27Bibliographically approved

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