Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
On the pore forming mechanism of Upsalite, a micro- and mesoporous magnesium carbonate
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanotechnology and Functional Materials)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)ORCID iD: 0000-0002-5496-9664
2014 (English)In: Microporous and Mesoporous Materials, ISSN 1387-1811, E-ISSN 1873-3093, Vol. 190, 99-104 p.Article in journal (Refereed) Published
Abstract [en]

This work analyzes the pore forming mechanism and stability of Upsalite; an extraordinary moisture absorbing, high-surface area magnesium carbonate powder synthesised without the use of surfactants as pore forming agents. The pores in Upsalite were found to be created in a two-step process where the first step includes the formation of micropores by solvent evaporation and release of physically bound carbon dioxide, acting as an in-situ pore-forming template. In the second step, the micropores expand to mesopores due to partial decomposition of organic groups on the surface of the pore walls when the material is stored in air at moderate temperatures (70 °C). The resulting material has a narrow pore size distribution centered at 5 nm, and the amorphous structure is stable upon storage in a humid atmosphere.

It was further shown that calcination at temperatures above 250 °C is required for complete removal of the organic surface groups in Upsalite. Prior to calcination, the organic groups present in the material act as barriers hindering water to induce crystallization of the bulk material. After calcination, however, Upsalite crystallizes into nesquehonite when stored at 100 % relative humidity for several days. The results presented herein are expected to be useful for the development of novel surfactant-free synthesis routes of porous materials as well as for the understanding of the long-term performance of such materials.

Place, publisher, year, edition, pages
2014. Vol. 190, 99-104 p.
Keyword [en]
pore forming mechanism, surfactant-free, in situ gas template, microporous, mesoporous, magnesium carbonate
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-212802DOI: 10.1016/j.micromeso.2013.12.011ISI: 000335102500014OAI: oai:DiVA.org:uu-212802DiVA: diva2:679306
Available from: 2013-12-14 Created: 2013-12-14 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Mesoporous magnesium carbonate: Synthesis, characterization and biocompatibility
Open this publication in new window or tab >>Mesoporous magnesium carbonate: Synthesis, characterization and biocompatibility
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Mesoporous materials constitute a promising class of nanomaterials for a number of applications due to their tunable pore structure. The synthesis of most mesoporous materials involves a surfactant liquid crystal structure to form the pores. As well as the many advantages associated with this method of synthesis, there are disadvantages such as high production costs and a substantial environmental impact which limit the possibilities for large scale production. Therefore there is a need for other synthesis routes.

The aim of the work described herein was to contribute to this field by developing a synthesis route that does not rely on surfactants for pore formation. A mesoporous magnesium carbonate material was therefore formed by self-assemblage of the particles around carbon dioxide gas bubbles, which functioned as pore templates. It was also possible to vary the pore diameter between 3 and 20 nm.

The biocompatibility of the formed magnesium carbonate material was evaluated in terms of in vitro cytotoxicity and hemocompatibility, in vivo skin irritation and acute systemic toxicity. The results from the in vitro cytotoxicity, in vivo skin irritation and acute systemic toxicity test using a polar extraction vehicle showed that the material was non-toxic. While signs of toxicity were observed in the acute systemic toxicity test using a non-polar solvent, this was attributed to injection of particles rather than toxic leachables. In the in vitro hemocompatibility test, no hemolytic activity was found with material concentrations of up to 1 mg/ml. It was further shown that the material had anticoagulant properties and induced moderate activation of the complement system. The anticoagulant properties were ascribed to uptake of Ca2+.

Finally, the ability of the material to increase the dissolution rate of the poorly soluble drug itraconazole was analyzed.  Itraconazole was dissolved up to 23 times faster from the magnesium carbonate pores than when the free drug was used. The release rate from the delivery vehicle was dependent on the pore diameter.

The work presented herein is expected to be useful for the development of alternative synthesis routes for mesoporous materials and also for encouraging the development of biomedical applications for these materials.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2016. 75 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1363
Keyword
mesoporous, magnesium carbonate, pore size control, cytotoxicity, in vivo, skin irritation, acute systemic toxicity, hemocompatibility, Ca2+ uptake, solubility enhancement
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-281522 (URN)978-91-554-9540-4 (ISBN)
Public defence
2016-05-20, Polhemssalen, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:30 (English)
Opponent
Supervisors
Available from: 2016-04-27 Created: 2016-03-24 Last updated: 2016-04-29

Open Access in DiVA

fulltext(1096 kB)345 downloads
File information
File name FULLTEXT01.pdfFile size 1096 kBChecksum SHA-512
3ff010614c28fba70170fbb3a11d5facfffe20e7263e461bcaefc3ce08b526a5aa0234203f3c0bade21efefc0e056b85f147aac3539b01c97d9f7f3f6f6b8cca
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Frykstrand, SaraForsgren, JohanMihranyan, AlbertStrömme, Maria
By organisation
Nanotechnology and Functional Materials
In the same journal
Microporous and Mesoporous Materials
Nano Technology

Search outside of DiVA

GoogleGoogle Scholar
Total: 345 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 1013 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf