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Development of an optical system for combined imaging and patterned stimulation of the rodentretina
KTH, School of Engineering Sciences (SCI), Physics.
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

During this Master’s thesis at the Vision Institute (Paris, France), a noncontact

optical system for

in vivo combined imaging and patterned stimulation

of the rodent eye was developed. The objective was to assess the

efficiency of the optogenetic therapy, currently tested on rodents, whose aim

is to heal blind or low-visual-acuity people.

To the best of our knowledge, previous systems did not reach the photometric

requirement needed for the stimulation of optogenetic channels and

were developed for bigger mammals than rodents. The mounted system allowed

us to obtain non-contact mouse and rat eye fundi images with a wide

field in both near-infrared and visible illumination. The first tests of the

patterned stimulation arm allowed projection of simple patterns on the rat

eye and showed that the photometric requirements are almost met for the

activation of optogenetic channels. Future developments should include stable

alignment of the animal’s eye with the optical axis of the system, which

would result in an improved quality of eye fundus images and of the patterned

stimulation.

Place, publisher, year, edition, pages
2013. , 36 p.
Series
Trita-FYS, ISSN 0280-316X ; TRITA-FYS 2013:69
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-134964OAI: oai:DiVA.org:kth-134964DiVA: diva2:669026
Subject / course
Engineering Physics
Supervisors
Examiners
Available from: 2013-12-02 Created: 2013-12-02 Last updated: 2013-12-02Bibliographically approved

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Master of Science Thesis final Paul Delrot(12605 kB)520 downloads
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CiteExportLink to record
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Citation style
  • apa
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