Investigation of the origin of the coronary artery calcification process and its relationship to the atherosclerotic cardiovascular disease
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
The objectives of this thesis are: a) To examine racial/ethnic differences in coronary artery calcification (CAC) and CAD, between symptomatic South Asians and Caucasians, matched for age, gender and conventional cardiovascular risk factors, b) To assess, using a meta-analysis model, the natural history of and stability of measurements of coronary artery calcium scoring (CACs) based on data collected from two large published trials: St Francis and EBEAT, c) To investigate the prevalence of coronary artery calcification in individuals with CT evidence for AVC, mitral valve calcification (MAC) or of both of them (AVC+MAC), d) To assess any potential association between premature CAD (<55 years in first-degree male relatives and <65 years in first-degree female relatives) and CAC in a large cohort of asymptomatic individuals.
We found that coronary artery calcification is more extensive and diffuse in symptomatic patients of South Asian ethnic origin as compared to Caucasians, despite similar conventional risk factors for CAD. This is more evident in those >50 years of age, suggesting potential genetic or other risk factors yet to be determined. The natural history of coronary artery calcification was overtime progression in the majority of subjects, irrespective of gender. The higher variability in RCA measurements could be related to the low baseline CACs or exaggerated movement of the right side atrioventricular ring, whereas those for LCA brances are influenced by the branch allocation of the CACs. Valve calcification is not isolated but involve also and the coronary arteries. The presence of calcification in the aortic valve or combined aortic and mitral valves predicted coronary artery calcification. Additionally patients in whom both valves have become calcified tend to have severe coronary artery calcification. And finally, there is no relationship between the prevalence and extent of coronary artery calcification and the presence of family history of coronary heart disease in asymptomatic individuals with none of the conventional risk factors for atherosclerosis.
Place, publisher, year, edition, pages
Umeå: Umeå universitet , 2013. , 90 p.
Umeå University medical dissertations, ISSN 0346-6612 ; 1619
Coronary artery calcification, ethnicity, South Asians, Caucasians, reproducibility, aortic valve calcification, mitral valve calcification, family history of coronary artery disease, natural history, coronary artery calcium score, meta-analysis
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:umu:diva-83450ISBN: 978-91-7459-774-5OAI: oai:DiVA.org:umu-83450DiVA: diva2:667332
2013-12-17, Sal D, unod T9, Norrlands universitetssjukhus, Umeå, 09:00 (English)
Engvall, Jan, Docent
Henein, MichaelÅhlström Riklund, Katrine
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