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Prevalence of tick-borne encephalitis virus in Ixodes ricinus ticks in northern Europe with particular reference to southern Sweden
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. (Medical Entomology Unit)
Department of Virology, National Institute for Health Development, Tallinn, Estonia.
Swedish Institute for Communicable Disease Control, Solna, Sweden.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. (Medical Entomology Unit)
2014 (English)In: Parasites & Vectors, ISSN 1756-3305, E-ISSN 1756-3305, Vol. 7, 102- p.Article in journal (Other academic) Published
Place, publisher, year, edition, pages
2014. Vol. 7, 102- p.
Keyword [en]
Ixodes ricinus, minimum infection rate, RT-PCR, Sweden, Norway, Denmark, Finland, TBE, tick-borne encephalitis virus, virus prevalence.
National Category
Biological Sciences Microbiology in the medical area Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-210857DOI: 10.1186/1756-3305-7-102ISI: 000335074400002OAI: oai:DiVA.org:uu-210857DiVA: diva2:665317
Available from: 2013-11-19 Created: 2013-11-15 Last updated: 2017-12-06Bibliographically approved
In thesis
1. The Origin of the Genus Flavivirus and the Ecology of Tick-Borne Pathogens
Open this publication in new window or tab >>The Origin of the Genus Flavivirus and the Ecology of Tick-Borne Pathogens
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The present thesis examines questions related to the temporal origin of the Flavivirus genus and the ecology of tick-borne pathogens. In the first study, we date the origin and divergence time of the Flavivirus genus. It has been argued that the first flaviviruses originated after the last glacial maximum. This has been contradicted by recent analyses estimating that the tick-borne flaviviruses emerged at least before 16,000 years ago. It has also been argued that the Powassan virus was introduced into North America at the time between the opening and splitting of the Beringian land bridge. Supported by tip date and biogeographical calibration, our results suggest that this genus originated circa 120,000 (156,100–322,700) years ago if the Tamana bat virus is included in the genus, or circa 85,000 (63,700–109,600) years ago excluding the Tamana bat virus. In the second study we estimate the prevalence of tick-borne encephalitis virus (TBEV) in host-seeking Ixodes ricinus from 29 localities in Sweden and compare our data with those of neighbouring countries. Nymphs and adult ticks were screened for TBEV using a real-time PCR assay. The mean TBEV prevalence for all tick stages combined was 0.26% for Sweden and 0.28% for all Scandinavian countries, excluding Iceland. The low prevalence of TBEV in nature may partly be explained by the fact that TBEV occurs in spatially small foci and that the inclusion of ticks from non-infected foci will reduce the prevalence estimate. In the third and fourth study, we conducted the first large-scale investigations to estimate the prevalence and geographical distribution of Anaplasma spp. and Rickettsia spp. in host-seeking larvae, nymphs and adults of I. ricinus ticks in Sweden. Ticks were collected from several localities in central and southern Sweden and were subsequently screened for the presence of Anaplasma spp. and Rickettsia spp. using a real-time PCR assay. For all active tick stages combined, the mean prevalence of Anaplasma spp. and Rickettsia spp. in I. ricinus in Sweden was estimated to 1.1% and 4.8%, respectively. It was also shown that A. phagocytophilum and R. helvetica are the main Anaplasma and Rickettsia species occurring in Sweden.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2013. 60 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1100
Keyword
Flavivirus, Virus dating, Molecular dating, Biogeography, Ixodes ricinus, Minimum infection rate, TBE, Tick-borne encephalitis virus, Rickettsia helvetica, Anaplasma phagocytophilum, Infection prevalence, RT-PCR
National Category
Biological Sciences
Research subject
Biology with specialization in Systematics
Identifiers
urn:nbn:se:uu:diva-211090 (URN)978-91-554-8814-7 (ISBN)
Public defence
2014-01-10, Zootissalen, EBC, Villavägen 9, Uppsala, 13:00 (English)
Opponent
Supervisors
Available from: 2013-12-10 Created: 2013-11-19 Last updated: 2014-01-24

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