Dating the origin of the genus Flavivirus in the light of Beringian biogeography
2014 (English)In: Journal of General Virology, ISSN 0022-1317, E-ISSN 1465-2099, Vol. 95, 1969-1982 p.Article in journal (Refereed) Published
The genus Flavivirus includes some of the most important human viral pathogens, and itsmembers are found in all parts of the populated world. The temporal origin of diversification of thegenus has long been debated due to the inherent problems with dating deep RNA virus evolution.A generally accepted hypothesis suggests that Flavivirus emerged within the last 10 000 years.However, it has been argued that the tick-borne Powassan flavivirus was introduced into NorthAmerica some time between the opening and closing of the Beringian land bridge that connectedAsia and North America 15 000–11 000 years ago, indicating an even older origin for Flavivirus.To determine the temporal origin of Flavivirus, we performed Bayesian relaxed molecular clockdating on a dataset with high coverage of the presently available Flavivirus diversity by combiningtip date calibrations and internal node calibration, based on the Powassan virus and Beringianland bridge biogeographical event. Our analysis suggested that Flavivirus originated ~85 000(64 000–110 000) or 120 000 (87 000–159 000) years ago, depending on the circumscriptionof the genus. This is significantly older than estimated previously. In light of our results, wepropose that it is likely that modern humans came in contact with several members of the genusFlavivirus much earlier than suggested previously, and that it is possible that the spread of severalflaviviruses coincided with, and was facilitated by, the migration and population expansion ofmodern humans out of Africa.
Place, publisher, year, edition, pages
2014. Vol. 95, 1969-1982 p.
Flavivirus, virus evolution, virus dating, Beringia, POWV, molecular clock, molecular dating
Biological Systematics Microbiology
IdentifiersURN: urn:nbn:se:uu:diva-210860DOI: 10.1099/vir.0.065227-0ISI: 000341800500012PubMedID: 24914065OAI: oai:DiVA.org:uu-210860DiVA: diva2:665316