Human gene variants linked to enhanced NLRP3 activity limit intramacrophage growth of Mycobacterium tuberculosis
2014 (English)In: The Journal of infectious diseases, ISSN 1537-6613, Vol. 209, no 5, 749-753 p.Article in journal (Refereed) Published
Activation of the NLRP3 inflammasome and subsequent generation of IL-1β is initiated in macrophages upon recognition of several stimuli. In the present work, we show that gain-of-function gene variants of inflammasome components known to predispose individuals to inflammatory disorders have a host-protective role during infection with Mycobacterium tuberculosis. By isolation of macrophages from patients and healthy blood donors with genetic variants in NLRP3 and CARD8 and subsequently infecting the cells by virulent M. tuberculosis, we show that these gene variants, combined, are associated with increased control of bacterial growth in human macrophages.
Place, publisher, year, edition, pages
University of Chicago Press / Oxford University Press (OUP) , 2014. Vol. 209, no 5, 749-753 p.
IdentifiersURN: urn:nbn:se:liu:diva-100889DOI: 10.1093/infdis/jit572ISI: 000331873700016PubMedID: 24158955OAI: oai:DiVA.org:liu-100889DiVA: diva2:664167