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An evaluation and improvement of an in vitro heart phantom of the hearts coronary circulation.
KTH, School of Technology and Health (STH).
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The purpose of this thesis has been to validate the in-vitro heart simulation model of the coronary arteries called Flowlab, identify limitations and potential problems, and to offer suggestions for improvement. Flowlab emulates arterial characteristics such as pressure and flow, providing a simulation environment with the ability to measure the volumetric coronary blood flow and arterial blood pressure. Compared to current simulation systems, this will give a better understanding of both position and severity of the cardiovascular disease, and also provide essential information regarding the hemodynamics in the coronary arteries.


To understand the fluid dynamics of the coronary system and gain a deeper understanding of the arterial function and physiology, the first phase of this thesis will focus on gathering information regarding the anatomy, physiology and hemodynamics of the coronary arteries. This will also be done to provide the Flowlab construction with appropriate measurements for the coronary simulation pipe, and input data for its final design.


The Flowlab construction will then be tested to verify the accuracy of the produced values compared with the sought after values of pressure and flow, to further enable an adjustment of the system.


The results from the test show that the final calibration of the simulation environment was not sufficient to produce an accurate result for both pressure and flow regulation, only flow. The flow had an accuracy of 10 %, while the generated pressure was underestimated at low pressures and overestimated at high pressure at up to 20 %. An accuracy of 10 % for generated flow is satisfying and sufficient; meanwhile the pressure calibration had to be altered for more reliable data.


The analysis also revealed several shortages in the design of the Flowlab system that needed to be adjusted for more consistent pressure and flow measurements.

Place, publisher, year, edition, pages
2013. , 85 p.
TRITA-STH, 2013:118
National Category
Medical Engineering
URN: urn:nbn:se:kth:diva-133775OAI: diva2:663278
Subject / course
Medical Engineering
Educational program
Master of Science in Engineering - Medical Engineering
2013-06-12, 10:54 (English)
Available from: 2014-03-05 Created: 2013-11-11 Last updated: 2014-03-05Bibliographically approved

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