Change search
ReferencesLink to record
Permanent link

Direct link
Effect of ultrasound on the distribution of nanoparticles in tumor tissue
Norwegian University of Science and Technology, Faculty of Natural Sciences and Technology, Department of Materials Science and Engineering.
2013 (English)MasteroppgaveStudent thesis
Abstract [en]

PC-3 prostate adenocarcinoma cells were injected subcutaneously in the hind leg of female Balb/c nude mice. After a few weeks of tumor growth, 200 $\mu$L of a solution containing gas bubbles stabilized by PBCA nanoparticles encapsulating nile red was intravenously administered. The mice were then divided into four treatment groups, three of which were treated with ultrasound, while the last group was not. The three different ultrasound treatments were (1) 1 MHz and MI = 0.1, (2) 1 MHz and MI = 0.4, and (3) 1 MHz and MI = 0.4 + 5 MHz and MI = 2.24. Blood vessels were stained using FITC-lectin. Freeze sections from the tumors were prepared and imaged in a confocal microscope. The images were quantitatively and qualitatively analyzed. No statistical difference was found between the different treatment groups from the quantitative analysis, as the standard deviations were too large. However, a qualitative difference could be observed between mice that were not treated with ultrasound and mice that were treated. It was concluded that the uptake in adipose tissue seemed to be improved after ultrasound.

Place, publisher, year, edition, pages
Institutt for fysikk , 2013. , 62 p.
URN: urn:nbn:no:ntnu:diva-23252Local ID: ntnudaim:9962OAI: diva2:659657
Available from: 2013-10-26 Created: 2013-10-26 Last updated: 2013-10-26Bibliographically approved

Open Access in DiVA

fulltext(34223 kB)632 downloads
File information
File name FULLTEXT01.pdfFile size 34223 kBChecksum SHA-512
Type fulltextMimetype application/pdf
cover(184 kB)3 downloads
File information
File name COVER01.pdfFile size 184 kBChecksum SHA-512
Type coverMimetype application/pdf

By organisation
Department of Materials Science and Engineering

Search outside of DiVA

GoogleGoogle Scholar
Total: 632 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 38 hits
ReferencesLink to record
Permanent link

Direct link