Mitochondrial translation initiation machinery: conservation and diversification
2014 (English)In: Biochimie, ISSN 0300-9084, E-ISSN 1638-6183, Vol. 100C, 132-140 p.Article in journal (Refereed) Published
The highly streamlined mitochondrial genome encodes almost exclusively a handful of transmembrane components of the respiratory chain complex. In order to ensure the correct assembly of the respiratory chain, the products of these genes must be produced in the correct stoichiometry and inserted into the membrane, posing a unique challenge to the mitochondrial translational system. In this review we describe the proteins orchestrating mitochondrial translation initiation: bacterial-like general initiation factors mIF2 and mIF3, as well as mitochondria-specific components - mRNA-specific translational activators and mRNA-nonspecific accessory initiation factors. We consider how the fast rate of evolution in these organelles has not only created a system that is divergent from that of its bacterial ancestors, but has led to a huge diversity in lineage specific mechanistic features of mitochondrial translation initiation among eukaryotes.
Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 100C, 132-140 p.
Mitochondria, Ribosome, IF2, IF3, Translational activators
Biochemistry and Molecular Biology Evolutionary Biology
IdentifiersURN: urn:nbn:se:umu:diva-81892DOI: 10.1016/j.biochi.2013.07.024ISI: 000335101400014PubMedID: 23954798OAI: oai:DiVA.org:umu-81892DiVA: diva2:658699