Change search
ReferencesLink to record
Permanent link

Direct link
Screening av humanvävnad
Executive, Universitet, Örebro universitet, Örebro universitet, forskningscentrum människa teknik miljö, MTM.
Executive, Universitet, Örebro universitet, Örebro universitet, forskningscentrum människa teknik miljö, MTM.
Executive, Universitet, Örebro universitet, Örebro universitet, forskningscentrum människa teknik miljö, MTM.
Responsible organisation
2008 (Swedish)Report (Other academic)Alternative title
Screening of persistent halogenated compounds in human adipose tissue and blood from Sweden (English)
Abstract [sv]

To expand our monitoring focus and to make complementary additions to the POPs traditionally measured we undertook a POP screening study of human tissue representative for Swedish adults in 2007. Among the compounds assessed in this study are several classes of organohalogen contaminants, such as polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) and their brominated homologues (PBDD/Fs), polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs), polybrominated diphenyl ethers (PBDEs) and other bromine containing compounds, a number of organochlorine Stockholm Convention pesticides including toxaphene, and several recently identified perfluorinated chemicals (PFCs). The analytical techniques used were based on various GC and HPLC massspectrometry applications after clean-up and fractionation of blood and adipose tissue samples. The profile of the PCDD/F in 2007 is considered to be unchanged since the 90’s. The shift in congener profile from BDE #47, earlier being the dominant congener in human tissues, to BDE# 153 being dominant is confirmed in this study. Levels of PCBs are lower in this study group in relation to earlier fish consumers’ levels. Six individual PFCs were detected in the blood samples analysed. PFOS was detected at the highest concentration, with a geometric mean of 16 ng/ml, followed by PFOA, 2,4 ng/ml, PFHxS, PFNA, PFDA and PFUnDA were present at similar levels. There is a need to further investigate individual exposures to PFCs and identify high exposure groups. Brominated PBDFs were found in human adipose at concentrations of 0.27-2.24 pg/g, being the first results on a larger material of the general population in Sweden. The screening of a larger sample seize of human adipose tissue revealed several unknown, bromine containing POPs. Both smaller and larger bromine containing compounds besides the known BDEs were found. Positive identification of these compounds will require authentic standards and high resolution GC/MS analysis.

Place, publisher, year, edition, pages
Örebro universitet, Människa-Teknik-Miljö forskningscentrum , 2008.
Keyword [en]
health, environment
Keyword [sv]
Örebro, blod, human vävnad, POP, serum, fettvävnad
National Category
Environmental Sciences
Research subject
Miljöövervakningens programområden, Toxic; Environmental Objectives, A Non-Toxic Environment
URN: urn:nbn:se:naturvardsverket:diva-176Local ID: 40006781-b30d-4176-95f7-5d1ef35bdc74OAI: diva2:657741
Available from: 2013-10-21 Created: 2013-10-21 Last updated: 2014-01-09Bibliographically approved

Open Access in DiVA

fulltext(661 kB)72 downloads
File information
File name FULLTEXT01.pdfFile size 661 kBChecksum SHA-512
Type fulltextMimetype application/pdf

By organisation
Örebro universitet, forskningscentrum människa teknik miljö, MTM
Environmental Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 72 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 35 hits
ReferencesLink to record
Permanent link

Direct link