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Biocompatibility of OSTE polymers studied by cell growth experiments
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9651-4900
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.ORCID iD: 0000-0003-3402-9672
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9177-1174
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2013 (English)In: Proceedings of the 17th Int. Conf. on Miniaturized Systems for Chemistry  and Life Sciences (microTAS), Freiburg, Germany, 2013Conference paper (Refereed)
Abstract [en]

The recently introduced OSTE polymer technology has shown very useful features for microfluidics for lab-on-a-chip applications. However, no data has yet been published on cell viability on OSTE. In this work, we study the biocompatibility of three OSTE formulations by cell growth experiments. Moreover, we investigate the effect of varying thiol excess on cell viability on OSTE surfaces. The results show poor cell viability on one OSTE formulation, and viability comparable with polystyrene on a second formulation with thiol excess below 60%. In the third formulation, we observe cell proliferation. These results are promising for cell-based assays in OSTE microfluidic devices.

Place, publisher, year, edition, pages
Freiburg, Germany, 2013.
Keyword [en]
loc OSTE lab-on-chip biocompatibility
National Category
Medical Materials
URN: urn:nbn:se:kth:diva-129546ScopusID: 2-s2.0-84907370206OAI: diva2:652888
The 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013), Freiburg, 27-31 October 2013
Swedish Research Council, B0460801EU, European Research Council, 267528

QC 20131122

Available from: 2013-10-02 Created: 2013-10-02 Last updated: 2015-06-12Bibliographically approved

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Errando-Herranz, CarlosVastesson, AlexanderZelenina, MarinaPardon, GaspardWijngaart, Wouter van derHaraldsson, TommyBrismar, HjalmarGylfason, Kristinn B.
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