Preoperative Topical Hypothermia used in Prolonged Severe Lower Limb Ischemia to Avoid Ischemic Damage - The First Clinical Experience
2013 (English)In: International Journal of Biomedical Science, ISSN 1550-9702, E-ISSN 1555-2810, Vol. 9, no 3, 181-184 p.Article in journal (Refereed) Published
Severe lower limb ischemia TASC IIB/III with sensory and motor neurologic deficiencies leads to prolonged hospital care, amputation, and death in 20-70 % of cases. We present our first clinical experience of the use of preoperative topical hypothermia to improve muscular viability in these patients. Two hours after onset of symptoms, six 4-liter plastic bags were filled with snow and packed against the ischemic leg which was protected from frost injury by a layer of towels. After surgical revascularization four hours later muscular and neural functions in the leg were completely restored. A maximum serum myoglobin of 6500 ng/L (median 12000 ng/L in similar but untreated patients) postoperatively decreased to 1400 ng/L after 27 hours.
Place, publisher, year, edition, pages
2013. Vol. 9, no 3, 181-184 p.
skeletal muscle; topical hypothermia; limb ischemia; ischemic damage; protection
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-98192OAI: oai:DiVA.org:liu-98192DiVA: diva2:652578